Genome-wide cancer mutation analyses are revealing an extensive landscape of functional
mutations within the noncoding genome, with profound effects on the expression of long …

It is increasingly evident that many of the genomic mutations in cancer reside inside regions
that do not encode proteins. However, these regions are often transcribed into long …

To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered
through functional genomics studies. Importantly, lncRNAs have been shown, in many …

The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

One of the long-standing principles of molecular biology is that DNA acts as a template for
transcription of messenger RNAs, which serve as blueprints for protein translation. A rapidly …

Since comprehensive analysis of the mammalian genome revealed that the majority of
genomic products are transcribed in long non‐coding RNA (lnc RNA), increasing attention …

The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …

Long noncoding RNAs (lncRNA) have been associated with various types of cancer;
however, the precise role of many lncRNAs in tumorigenesis remains elusive. Here we …

Colorectal cancer (CRC) is a leading cause of death worldwide, despite progress made in
detection and management through surgery, chemotherapy, radiotherapy, and …

Transcription and translation are two main pillars of gene expression. Due to the different
timings, spots of action, and mechanisms of regulation, these processes are mainly …