Abstract Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with
reduced performance on multiple domains of cognitive function and with evidence of …

As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …

Obesity is a growing problem worldwide and is associated with a range of comorbidities,
including cognitive dysfunction. In this review we will address the evidence that obesity and …

Scope: it has been suggested that overweight/obesity as a risk factor for incident dementia
differs between mid-life and later life. We performed a systematic review and meta-analysis …

The global prevalence of dementia has been estimated to be as high as 24 million, and is
predicted to double every 20 years until at least 2040. As the population worldwide …

Compelling evidence from basic molecular biology has demonstrated the dual roles of
microglia in the pathogenesis of Alzheimer's disease (AD). On one hand, microglia are …

Obesity is defined as abnormal and excessive fat accumulation, and it is a risk factor for
develo** metabolic and neurodegenerative diseases and cognitive deficits. Obesity is …

The global prevalence of dementia is estimated to be as high as 24 million, and is predicted
to double every 20 years through to 2040, leading to a costly burden of disease. Alzheimer …

The incidence of obesity in middle age is increasing markedly, and in parallel the
prevalence of metabolic disorders including cardiovascular disease and type II diabetes is …

Estrogen is a fundamental regulator of the metabolic system of the female brain and body.
Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial …