The genetic correlation describes the genetic relationship between two traits and can
contribute to a better understanding of the shared biological pathways and/or the causality …

Asthma is a heterogeneous disease that results from the complex interaction between
genetic factors and environmental exposures that occur at critical periods throughout life. It …

Emerging evidence has suggested a close correlation between COVID-19 and
neurodegenerative disorders. However, whether there exists a causal association and the …

Genetic correlation (rg) analysis is used to identify phenotypes that may have a shared
genetic basis. Traditionally, rg is studied globally, considering only the average of the …

Poor trans-ancestry portability of polygenic risk scores is a consequence of Eurocentric
genetic studies and limited knowledge of shared causal variants. Leveraging regulatory …

Local genetic correlation quantifies the genetic similarity of complex traits in specific
genomic regions. However, accurate estimation of local genetic correlation remains …

Almost every recent Alzheimer's disease (AD) genome-wide association study (GWAS) has
performed meta-analysis to combine studies with clinical diagnosis of AD with studies that …

Many diseases exhibit population-specific causal effect sizes with trans-ethnic genetic
correlations significantly less than 1, limiting trans-ethnic polygenic risk prediction. We …

The development of polygenic risk scores (PRSs) has proved useful to stratify the general
European population into different risk groups. However, PRSs are less accurate in non …

Here we report a large genome-wide association study (GWAS) for longitudinal smoking
phenotypes in 286,118 individuals from the Million Veteran Program (MVP) where we …