Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

More than one-third of the worldwide population is overweight or obese and therefore at risk
of develo** type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

Aging is underpinned by pronounced metabolic decline; however, the drivers remain
obscure. Here, we report that IgG accumulates during aging, particularly in white adipose …

INTRODUCTION All body cells rely on blood vessels (BVs) for the provision of oxygen and
other blood-borne substances and, in certain settings, also for the provision of endothelial …

Beige fat plays key roles in the regulation of systemic energy homeostasis; however,
detailed mechanisms and safe strategy for its activation remain elusive. In this study, we …

Objective A novel dual GIP and GLP-1 receptor agonist, LY3298176, was developed to
determine whether the metabolic action of GIP adds to the established clinical benefits of …

Measurement of oxygen consumption is a powerful and uniquely informative experimental
technique. It can help identify mitochondrial mechanisms of action following pharmacologic …

The development of single-molecule co-agonists for the glucagon-like peptide-1 (GLP-1)
receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) …

Objective Eating earlier in the daytime to align with circadian rhythms in metabolism
enhances weight loss. However, it is unknown whether these benefits are mediated through …

Uncertainty exists as to whether the glucose-dependent insulinotropic polypeptide receptor
(GIPR) should be activated or inhibited for the treatment of obesity. Gipr was recently …