Toxins that pass through the blood-brain barrier put neurons and glia in peril. The damage
inflicted is usually a consequence of the ability of these toxic agents to induce free radical …

Iron is essential for normal neurological function because of its role in oxidative metabolism
and because it is a cofactor in the synthesis of neurotransmitters and myelin. In the past …

Acute hepatic porphyrias (AHP) can cause severe neurological symptoms involving the
central, autonomic, and peripheral nervous system. Due to their relative rarity and their …

The biosynthesis of porphyrins is one of the most conserved parthways known, about the
same sequence of reactions taking place in all species. By associating different metals …

Linalool is a monoterpene compound reported to be a major component of essential oils of
several aromatic species. Several linalool‐producing species are used in traditional medical …

Little is known about the movement of 5-aminolevulinic acid (δ-aminolevulinic acid; ALA)
between blood and brain. This is despite the fact that increases in brain ALA may be …

The increasing exposure of human populations to excessive levels of metals continues to
represent a matter of public health concern. Several biomarkers have been studied and …

Abstract δ-ALA-D is a metalloenzyme that has 3 vicinal thiol/thiolate groups that coordinate
with Zn (ii). The proximity between the sulfhydryl groups renders δ-ALA-D extremely …

Acute intermittent porphyria (AIP) is an autosomal dominant disease caused by mutations in
porphobilinogen deaminase (PBGD), the third enzyme of the heme synthesis pathway …

Acute intermittent porphyria (AIP) is an inherited metabolic disease due to a deficiency of the
hydroxymethylbilane synthase in the haem biosynthesis. It manifests with occasional …