Despite its abundance in the environment, iron is poorly bioavailable and subject to strict
conservation and internal recycling by most organisms. In vertebrates, the stability of iron …

Tumor-associated macrophages (TAMs) are some of the most abundant immune cells within
tumors and perform a broad repertoire of functions via diverse phenotypes. On the basis of …

This is the fifth in the series of reviews developed as part of the Biomarkers of Nutrition for
Development (BOND) program. The BOND Iron Expert Panel (I-EP) reviewed the extant …

Obesity is an excessive adipose tissue accumulation that may have detrimental effects on
health. Particularly, childhood obesity has become one of the main public health problems in …

What happens to inorganic nanoparticles (NPs), such as plasmonic gold or silver,
superparamagnetic iron oxide, or fluorescent quantum dot NPs after they have been …

Macrophages are sentinel cells of the innate immune system and have important functions
in development, tissue homeostasis, and immunity. These phylogenetically ancient cells …

Splenic red pulp macrophages (RPM) degrade senescent erythrocytes and recycle heme-
associated iron. The transcription factor SPI-C is selectively expressed by RPM and is …

Macrophages play crucial roles in innate immune response and in the priming of adaptive
immunity, and are characterized by their phenotypic heterogeneity and plasticity …

Osteoporosis is a frequent problem in disorders characterized by iron overload, such as the
thalassemias and hereditary hemochromatosis. The exact role of iron in the development of …

The long term outcome of nanoparticles in the organism is one of the most important
concerns raised by the development of nanotechnology and nanomedicine. Little is known …