Ventilator-associated pneumonia (VAP) is one of the most frequent ICU-acquired infections.
Reported incidences vary widely from 5 to 40% depending on the setting and diagnostic …

Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Background Whether proton-pump inhibitors are beneficial or harmful for stress ulcer
prophylaxis in critically ill patients undergoing invasive ventilation is unclear. Methods In this …

Abstract The European Resuscitation Council (ERC) and the European Society of Intensive
Care Medicine (ESICM) have collaborated to produce these post-resuscitation care …

The purpose of this document is to highlight practical recommendations to assist acute care
hospitals to prioritize and implement strategies to prevent ventilator-associated pneumonia …

Most randomized trials are designed and analyzed using frequentist statistical approaches
such as null hypothesis testing and P values. Conceptually, P values are cumbersome to …

Randomised clinical trials (RCTs) are the gold standard for providing unbiased evidence of
intervention effects. Here, we provide an overview of the history of RCTs and discuss the …

Acute kidney injury (AKI) is defined by a rapid increase in serum creatinine, decrease in
urine output, or both. AKI occurs in approximately 10–15% of patients admitted to hospital …

Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid decline in renal
function, and is associated with a high risk of death. Many pathological changes happen in …