DNA charge transport (CT) chemistry has received considerable attention by scientific
researchers over the past 15 years since our first provocative publication on long-range CT …

The fidelity of DNA polymerases is largely attributable to a two-step nucleotide binding
mechanism. In the first step, binding contacts are initially made between the template and …

Thermodynamics of 39 oligonucleotides with internal G⊙ T mismatches dissolved in 1 M
NaCl were determined from UV absorbance versus temperature profiles. These data were …

A common point of reference is needed to describe the three-dimensional arrangements of
bases and base-pairs in nucleic acid structures. The different standards used in computer …

DNA polymerase β (pol β) fills single nucleotide (nt) gaps in DNA produced by the base
excision repair pathway of mammalian cells. Crystal structures have been determined …

We describe the 2.6 Å resolution crystal structure of RB69 DNA polymerase with primer-
template DNA and dTTP, capturing the step just before primer extension. This ternary …

The observed sequence dependence of the mean twist angles in 38B-DNA crystal structures
can be understood in terms of simple geometrical features of the constituent base-pairs …

Accurate DNA replication is essential for genomic stability. One mechanism by which high-
fidelity DNA polymerases maintain replication accuracy involves stalling of the polymerase …

DNA polymerase δ (Pol δ) is a high-fidelity polymerase that has a central role in replication
from yeast to humans. We present the crystal structure of the catalytic subunit of yeast Pol δ …

The structure and dynamics of all the transversion and transition mismatches in three
different DNA environments have been characterized by molecular dynamics simulations …