The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

Langerhans cell histiocytosis (LCH) is caused by clonal expansion of myeloid precursors
that differentiate into CD1a+/CD207+ cells in lesions that leads to a spectrum of organ …

With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 in
3 infants with multisystemic disease involving the liver and hematopoietic system. This entity …

Histiocytoses constitute a heterogeneous group of rare disorders, characterised by
infiltration of almost any organ by myeloid cells with diverse macrophage or dendritic cell …

Neurodegenerative diseases (ND) are characterized by progressive loss of neuronal
function. Mechanisms of ND pathogenesis are incompletely understood, hampering the …

Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder caused by somatic genetic
alterations in hematopoietic precursor cells differentiating into CD1a+/CD207+ histiocytes …

Langerhans cell histiocytosis (LCH) is a rare, heterogenous, neoplastic disorder primarily
affecting children. BRAF mutations have been reported in> 50% of patients with LCH. The …

The standard treatment for Langerhans cell histiocytosis (LCH) is chemotherapy, although
the failure rates are high. Since MAP-kinase activating mutations are found in most cases …

Children with Langerhnans cell histiocytosis (LCH) develop granulomatous lesions with
characteristic clonal CD207+ dendritic cells that can arise as single lesions or life …