The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis
Background Patients with critical illness can lose more than 15% of muscle mass in one
week, and this can have long-term detrimental effects. However, there is currently no …
week, and this can have long-term detrimental effects. However, there is currently no …
[HTML][HTML] The underappreciated role of low muscle mass in the management of malnutrition
Preserving muscle is not only crucial for maintaining proper physical movement, but also for
its many metabolic and homeostatic roles. Low muscle mass has been shown to adversely …
its many metabolic and homeostatic roles. Low muscle mass has been shown to adversely …
Decreased fatty acid oxidation and altered lactate production during exercise in patients with post-acute COVID-19 syndrome
After acute infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), many individuals experience a range of symptoms including dyspnea, exercise …
2), many individuals experience a range of symptoms including dyspnea, exercise …
Skeletal muscle wasting and function impairment in intensive care patients with severe COVID-19
Background: Intensive care patients commonly develop muscle wasting and functional
impairment. However, the role of severe COVID-19 in the magnitude of muscle wasting and …
impairment. However, the role of severe COVID-19 in the magnitude of muscle wasting and …
[HTML][HTML] Restoring the infected powerhouse: Mitochondrial quality control in sepsis
FML Chavez, LP Gartzke, FE Van Beuningen, SE Wink… - Redox biology, 2023 - Elsevier
Sepsis is a dysregulated host response to an infection, characterized by organ failure. The
pathophysiology is complex and incompletely understood, but mitochondria appear to play a …
pathophysiology is complex and incompletely understood, but mitochondria appear to play a …
Muscle protein synthesis after protein administration in critical illness
Rationale: Dietary protein may attenuate the muscle atrophy experienced by patients in the
ICU, yet protein handling is poorly understood. Objectives: To quantify protein digestion and …
ICU, yet protein handling is poorly understood. Objectives: To quantify protein digestion and …
Elevated urea-to-creatinine ratio provides a biochemical signature of muscle catabolism and persistent critical illness after major trauma
Purpose Muscle wasting is common amongst patients with persistent critical illness and
associated with increased urea production, but reduced creatinine production. We …
associated with increased urea production, but reduced creatinine production. We …
Intensive care unit-acquired weakness: not just another muscle atrophying condition
Intensive care unit-acquired weakness (ICUAW) occurs in critically ill patients stemming from
the critical illness itself, and results in sustained disability long after the ICU stay. Weakness …
the critical illness itself, and results in sustained disability long after the ICU stay. Weakness …
Effect of intermittent or continuous feed on muscle wasting in critical illness: a phase 2 clinical trial
AS McNelly, DE Bear, BA Connolly, G Arbane, L Allum… - Chest, 2020 - Elsevier
Background Acute skeletal muscle wasting in critical illness is associated with excess
morbidity and mortality. Continuous feeding may suppress muscle protein synthesis as a …
morbidity and mortality. Continuous feeding may suppress muscle protein synthesis as a …
[HTML][HTML] Intensive care unit–acquired weakness: unanswered questions and targets for future research
Intensive care unit–acquired weakness (ICU-AW) is the most common neuromuscular
impairment in critically ill patients. We discuss critical aspects of ICU-AW that have not been …
impairment in critically ill patients. We discuss critical aspects of ICU-AW that have not been …