Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional
induction of a series of genes that participate in angiogenesis, iron metabolism, glucose …

Angiogenesis is essential for tumor growth, metastasis, arteriosclerosis as well as embryonic
development and wound healing. Its process is dependent on cell proliferation, migration …

Studies on erythropoietin regulation led to discovery of hypoxia-inducible factor 1 (HIF-1), a
transcription factor which is central component of oxygen sensing mechanism in mammalian …

Cellular oxygen partial pressure is sensed by a family of prolyl-4-hydroxylase domain (PHD)
enzymes that modify hypoxia-inducible factor (HIF) α subunits. Upon hydroxylation under …

Amyloid-β (Aβ) peptides play a key role in the pathogenesis of Alzheimer's disease and
exert various toxic effects on neurons; however, relatively little is known about their influence …

Reactive oxygen species (ROS) have long been considered as cytotoxic. However, recent
evidence indicates a prominent role of ROS as signaling molecules in the response to …

The mammalian target of rapamycin (mTOR) pathway plays a central role in regulating
protein synthesis, ribosomal protein translation, and cap-dependent translation …

Cadmium is categorized as a human carcinogen especially involved in lung cancers.
Angiogenesis is considered a fundamental requirement for tumorigenesis, but the …

We examined the influence of ROS on the phosphorylation and complex formation of Bcl‐2
family proteins in Mn‐superoxide dis‐mutase (SOD) antisense‐transfected squamous cell …