Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

It is reported that approximately 40 million people are suffering from dementia, globally.
Dementia is a group of symptoms that affect neurons and cause some mental disorders …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alpha-synuclein is a protein implicated in Parkinson's disease and thought to be one of the
main pathological drivers in the disease, although it remains unclear how this protein elicits …

Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

RIP1 and RIP3 kinases are central players in TNF-induced programmed necrosis. Here, we
report that the RIP homotypic interaction motifs (RHIMs) of RIP1 and RIP3 mediate the …

The aggregation of specific proteins is hypothesized to underlie several degenerative
diseases, which are collectively known as amyloid disorders. However, the mechanistic …

Phytochemicals are known to have anti-inflammatory effects in vitro and in vivo, such as in
inflammatory disease model systems. Inflammation is an essential immune response to …

The transparency of the eye lens depends on maintaining the native tertiary structures and
solubility of the lens crystallin proteins over a lifetime. Cataract, the leading cause of …

Diabetes mellitus has been recognized since antiquity. It currently affects as many as 285
million people worldwide and results in heavy personal and national economic burdens …