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Ocular drug delivery barriers—role of nanocarriers in the treatment of anterior segment ocular diseases
Ocular drug delivery is challenging due to the presence of anatomical and physiological
barriers. These barriers can affect drug entry into the eye following multiple routes of …
barriers. These barriers can affect drug entry into the eye following multiple routes of …
[HTML][HTML] Chitosan and its derivatives for ocular delivery formulations: Recent advances and developments
Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the
deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has …
deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has …
Effect of polymer-based nanoparticles on the assay of antimicrobial drug delivery systems
At the present time, infectious diseases maintain the importance among the reasons of
deaths in the world. The main reasons of this situation are the antibiotic resistance of …
deaths in the world. The main reasons of this situation are the antibiotic resistance of …
Nanosuspensions in ophthalmology: Overcoming challenges and enhancing drug delivery for eye diseases
This review article provides a comprehensive overview of the advancements in using
nanosuspensions for controlled drug delivery in ophthalmology. It highlights the significance …
nanosuspensions for controlled drug delivery in ophthalmology. It highlights the significance …
[HTML][HTML] Spanlastic-laden in situ gel as a promising approach for ocular delivery of Levofloxacin: In-vitro characterization, microbiological assessment, corneal …
The objective of this study was to encapsulate the antibacterial drug levofloxacin
hemihydrate (LF) into spanlastics (SLs) followed by incorporation into gelrite in situ gel to …
hemihydrate (LF) into spanlastics (SLs) followed by incorporation into gelrite in situ gel to …
Nanotransfersomes-loaded thermosensitive in situ gel as a rectal delivery system of tizanidine HCl: preparation, in vitro and in vivo performance
The purpose of the current study was to develop tizanidine HCl (TIZ; a myotonolytic agent
used for treatment of spasticity) loaded nanotransfersomes intended for rectal …
used for treatment of spasticity) loaded nanotransfersomes intended for rectal …
Absorption enhancement strategies in chitosan-based nanosystems and hydrogels intended for ocular delivery: Latest advances for optimization of drug permeation
I Dmour - Carbohydrate Polymers, 2024 - Elsevier
Ophthalmic diseases can be presented as acute diseases like allergies, ocular infections,
etc., or chronic ones that can be manifested as a result of systemic disorders, like diabetes …
etc., or chronic ones that can be manifested as a result of systemic disorders, like diabetes …
5-Fluorouracil shell-enriched solid lipid nanoparticles (SLN) for effective skin carcinoma treatment
RA Khallaf, HF Salem, A Abdelbary - Drug delivery, 2016 - Taylor & Francis
Context: The effective treatment of skin carcinoma is warranted for targeting the
chemotherapeutic agents into tumor cells and avoiding unwanted systemic absorption …
chemotherapeutic agents into tumor cells and avoiding unwanted systemic absorption …
In vitro/in vivo evaluation of an optimized fast dissolving oral film containing olanzapine co-amorphous dispersion with selected carboxylic acids
EM Maher, AMA Ali, HF Salem, AA Abdelrahman - Drug delivery, 2016 - Taylor & Francis
Improvement of water solubility, dissolution rate, oral bioavailability, and reduction of first
pass metabolism of OL (OL), were the aims of this research. Co-amorphization of OL …
pass metabolism of OL (OL), were the aims of this research. Co-amorphization of OL …
[HTML][HTML] Development and optimization of ciprofloxacin HCl-loaded chitosan nanoparticles using box–behnken experimental design
Various chitosan (CS)-based nanoparticles (CS-NPs) of ciprofloxacin hydrochloride (CHCl)
have been investigated for therapeutic delivery and to enhance antimicrobial efficacy …
have been investigated for therapeutic delivery and to enhance antimicrobial efficacy …