Ocular drug delivery barriers—role of nanocarriers in the treatment of anterior segment ocular diseases

RD Bachu, P Chowdhury, ZHF Al-Saedi, PK Karla… - Pharmaceutics, 2018 - mdpi.com
Ocular drug delivery is challenging due to the presence of anatomical and physiological
barriers. These barriers can affect drug entry into the eye following multiple routes of …

[HTML][HTML] Chitosan and its derivatives for ocular delivery formulations: Recent advances and developments

A Zamboulis, S Nanaki, G Michailidou, I Koumentakou… - Polymers, 2020 - mdpi.com
Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the
deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has …

Effect of polymer-based nanoparticles on the assay of antimicrobial drug delivery systems

M Gumustas, CT Sengel-Turk, A Gumustas… - … systems for combined …, 2017 - Elsevier
At the present time, infectious diseases maintain the importance among the reasons of
deaths in the world. The main reasons of this situation are the antibiotic resistance of …

Nanosuspensions in ophthalmology: Overcoming challenges and enhancing drug delivery for eye diseases

S Fathi-Karkan, NA Ramsheh, H Arkaban… - International Journal of …, 2024 - Elsevier
This review article provides a comprehensive overview of the advancements in using
nanosuspensions for controlled drug delivery in ophthalmology. It highlights the significance …

[HTML][HTML] Spanlastic-laden in situ gel as a promising approach for ocular delivery of Levofloxacin: In-vitro characterization, microbiological assessment, corneal …

OA Agha, GNS Girgis, MMA El-Sokkary… - International Journal of …, 2023 - Elsevier
The objective of this study was to encapsulate the antibacterial drug levofloxacin
hemihydrate (LF) into spanlastics (SLs) followed by incorporation into gelrite in situ gel to …

Nanotransfersomes-loaded thermosensitive in situ gel as a rectal delivery system of tizanidine HCl: preparation, in vitro and in vivo performance

FA Moawad, AA Ali, HF Salem - Drug delivery, 2017 - Taylor & Francis
The purpose of the current study was to develop tizanidine HCl (TIZ; a myotonolytic agent
used for treatment of spasticity) loaded nanotransfersomes intended for rectal …

Absorption enhancement strategies in chitosan-based nanosystems and hydrogels intended for ocular delivery: Latest advances for optimization of drug permeation

I Dmour - Carbohydrate Polymers, 2024 - Elsevier
Ophthalmic diseases can be presented as acute diseases like allergies, ocular infections,
etc., or chronic ones that can be manifested as a result of systemic disorders, like diabetes …

5-Fluorouracil shell-enriched solid lipid nanoparticles (SLN) for effective skin carcinoma treatment

RA Khallaf, HF Salem, A Abdelbary - Drug delivery, 2016 - Taylor & Francis
Context: The effective treatment of skin carcinoma is warranted for targeting the
chemotherapeutic agents into tumor cells and avoiding unwanted systemic absorption …

In vitro/in vivo evaluation of an optimized fast dissolving oral film containing olanzapine co-amorphous dispersion with selected carboxylic acids

EM Maher, AMA Ali, HF Salem, AA Abdelrahman - Drug delivery, 2016 - Taylor & Francis
Improvement of water solubility, dissolution rate, oral bioavailability, and reduction of first
pass metabolism of OL (OL), were the aims of this research. Co-amorphization of OL …

[HTML][HTML] Development and optimization of ciprofloxacin HCl-loaded chitosan nanoparticles using box–behnken experimental design

NM Soliman, F Shakeel, N Haq, FK Alanazi, S Alshehri… - Molecules, 2022 - mdpi.com
Various chitosan (CS)-based nanoparticles (CS-NPs) of ciprofloxacin hydrochloride (CHCl)
have been investigated for therapeutic delivery and to enhance antimicrobial efficacy …