Closely associated with aging and age-related disorders, cellular senescence (CS) is the
inability of cells to proliferate due to accumulated unrepaired cellular damage and …

Cellular senescence is an irreversible growth arrest that occurs as a result of different
damaging stimuli, including DNA damage, telomere shortening and dysfunction or …

The modification of eukaryotic proteins by isoprenoid lipids, which is known as prenylation,
controls the localization and activity of a range of proteins that have crucial functions in …

The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. Laminopathies are diseases caused by mutations in genes encoding …

As a compartment border, the nuclear envelope (NE) needs to serve as both a protective
membrane shell for the genome and a versatile communication interface between the …

The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …

Defects in the prelamin A processing enzyme caused by loss-of-function mutations in the
ZMPSTE24 gene are responsible for a spectrum of progeroid disorders characterized by the …

Mutations in nuclear lamins or other proteins of the nuclear envelope are the root cause of a
group of phenotypically diverse genetic disorders known as laminopathies, which have …

Hutchinson-Gilford progeria syndrome (HGPS) is caused by a point mutation in the LMNA
gene that activates a cryptic donor splice site and yields a truncated form of prelamin A …

Nuclear lamins are intermediate filament proteins that polymerize to form the nuclear lamina
on the inner aspect of the inner nuclear membrane. Long known to be essential for …