[HTML][HTML] Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data
Vortioxetine, a novel antidepressant for the treatment of major depressive disorder (MDD), is
a 5-HT 3, 5-HT 7 and 5-HT 1D receptor antagonist, 5-HT 1B receptor partial agonist, 5-HT …
a 5-HT 3, 5-HT 7 and 5-HT 1D receptor antagonist, 5-HT 1B receptor partial agonist, 5-HT …
The neurobiology and control of anxious states
MJ Millan - Progress in neurobiology, 2003 - Elsevier
Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …
(external and internal) stimuli which threaten to perturb homeostasis. However, when …
Molecular imaging in drug discovery and development
Imaging sciences have grown exponentially during the past three decades, and many
techniques, such as magnetic resonance imaging, nuclear tomographic imaging and X-ray …
techniques, such as magnetic resonance imaging, nuclear tomographic imaging and X-ray …
Serotonin modulation of cortical neurons and networks
The serotonergic pathways originating in the dorsal and median raphe nuclei (DR and MnR,
respectively) are critically involved in cortical function. Serotonin (5-HT), acting on …
respectively) are critically involved in cortical function. Serotonin (5-HT), acting on …
The therapeutic role of 5-HT1A and 5-HT2A receptors in depression
The selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed
antidepressant drugs, because they are well tolerated and have no severe side effects. They …
antidepressant drugs, because they are well tolerated and have no severe side effects. They …
Is there a role for 5-HT1A agonists in the treatment of depression?
P Blier, NM Ward - Biological psychiatry, 2003 - Elsevier
The role of serotonin (5-hydroxytryptamine; 5-HT) in the treatment of depressive and anxiety
disorders is underscored by the therapeutic action of selective 5-HT reuptake inhibitors …
disorders is underscored by the therapeutic action of selective 5-HT reuptake inhibitors …
Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions …
D Martinez, M Slifstein, A Broft… - Journal of Cerebral …, 2003 - journals.sagepub.com
The human striatum is functionally organized into limbic, associative, and sensorimotor
subdivisions, which process information related to emotional, cognitive, and motor function …
subdivisions, which process information related to emotional, cognitive, and motor function …
Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application
MJ Millan - Pharmacology & therapeutics, 2006 - Elsevier
Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …
high social cost. Depressed patients generally display co-morbid symptoms, and depression …
Serotonin 5-HT1A Receptors as Targets for Agents to Treat Psychiatric Disorders: Rationale and Current Status of Research
Psychiatric disorders represent a large economic burden in modern societies. However,
pharmacological treatments are still far from optimal. Drugs used in the treatment of major …
pharmacological treatments are still far from optimal. Drugs used in the treatment of major …
Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography: I. Accuracy and Precision of D2 Receptor Parameter Measurements in …
O Mawlawi, D Martinez, M Slifstein… - Journal of Cerebral …, 2001 - journals.sagepub.com
Dopamine transmission in the ventral striatum (VST), a structure which includes the nucleus
accumbens, ventral caudate, and ventral putamen, plays a critical role in the …
accumbens, ventral caudate, and ventral putamen, plays a critical role in the …