Antimicrobial peptides: An alternative to traditional antibiotics

S Ji, F An, T Zhang, M Lou, J Guo, K Liu, Y Zhu… - European Journal of …, 2024 - Elsevier
As antibiotic-resistant bacteria and genes continue to emerge, the identification of effective
alternatives to traditional antibiotics has become a pressing issue. Antimicrobial peptides …

Antimicrobial peptides: an update on classifications and databases

A Bin Hafeez, X Jiang, PJ Bergen, Y Zhu - International journal of …, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and are an
indispensable component of host defenses. They consist of predominantly short cationic …

Identification of potent antimicrobial peptides via a machine-learning pipeline that mines the entire space of peptide sequences

J Huang, Y Xu, Y Xue, Y Huang, X Li, X Chen… - Nature Biomedical …, 2023 - nature.com
Systematically identifying functional peptides is difficult owing to the vast combinatorial
space of peptide sequences. Here we report a machine-learning pipeline that mines the …

CAMPR4: a database of natural and synthetic antimicrobial peptides

U Gawde, S Chakraborty, FH Waghu… - Nucleic Acids …, 2023 - academic.oup.com
There has been an exponential increase in the design of synthetic antimicrobial peptides
(AMPs) for its use as novel antibiotics. Synthetic AMPs are substantially enriched in residues …

sAMPpred-GAT: prediction of antimicrobial peptide by graph attention network and predicted peptide structure

K Yan, H Lv, Y Guo, W Peng, B Liu - Bioinformatics, 2023 - academic.oup.com
Abstract Motivation Antimicrobial peptides (AMPs) are essential components of therapeutic
peptides for innate immunity. Researchers have developed several computational methods …

DBAASP v3: database of antimicrobial/cytotoxic activity and structure of peptides as a resource for development of new therapeutics

M Pirtskhalava, AA Amstrong, M Grigolava… - Nucleic acids …, 2021 - academic.oup.com
Abstract The Database of Antimicrobial Activity and Structure of Peptides (DBAASP) is an
open-access, comprehensive database containing information on amino acid sequences …

Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides

A Pandi, D Adam, A Zare, VT Trinh, SL Schaefer… - Nature …, 2023 - nature.com
Bioactive peptides are key molecules in health and medicine. Deep learning holds a big
promise for the discovery and design of bioactive peptides. Yet, suitable experimental …

ToxinPred 3.0: An improved method for predicting the toxicity of peptides

AS Rathore, S Choudhury, A Arora, P Tijare… - Computers in Biology …, 2024 - Elsevier
Toxicity emerges as a prominent challenge in the design of therapeutic peptides, causing
the failure of numerous peptides during clinical trials. In 2013, our group developed …

APD3: the antimicrobial peptide database as a tool for research and education

G Wang, X Li, Z Wang - Nucleic acids research, 2016 - academic.oup.com
The antimicrobial peptide database (APD, http://aps. unmc. edu/AP/) is an original database
initially online in 2003. The APD2 (2009 version) has been regularly updated and further …

Antioxidant and antimicrobial peptides derived from food proteins

G López-García, O Dublan-García, D Arizmendi-Cotero… - Molecules, 2022 - mdpi.com
Recently, the demand for food proteins in the market has increased due to a rise in
degenerative illnesses that are associated with the excessive production of free radicals and …