An abundance of evidence shows supporting roles for tetraspanin proteins in human cancer.
Many studies show that the expression of tetraspanins correlates with tumour stage, tumour …

Obinutuzumab (GA101) is a novel, type II, glycoengineered, humanized anti-CD20
monoclonal antibody that has been developed to address the need for new therapeutics …

Broadly neutralizing antibodies (bNAbs) against HIV-1 provide both effective pre-exposure
prophylaxis and treatment of HIV-1 infection in murine and nonhuman primate models …

We report the first preclinical in vitro and in vivo comparison of GA101 (obinutuzumab), a
novel glycoengineered type II CD20 monoclonal antibody, with rituximab and ofatumumab …

Introduction: Immunotherapy using mAbs is a safe and effective method for the treatment of
chronic lymphocytic leukemia (CLL) and other lymphoid malignancies. In recent years …

Today, monoclonal immunoglobulin gamma (IgG) antibodies have become a major option in
cancer therapy especially for the patients with advanced or metastatic cancers. Efficacy of …

Disease Overview: Chronic lymphocytic leukemia (CLL) is the commonest leukemia in
western countries. The disease typically occurs in elderly patients and has a highly variable …

Therapeutic monoclonal antibodies (mAbs) are mostly used in cancer, as anti-infectious
agents and as immunomodulatory drugs, and are amongst the most active area of research …

Abstract CD37 (tetraspanin TSPAN26) is a B-cell surface antigen widely expressed on
mature B cells. CD37 is involved in immune regulation and tumor suppression but its …

Tetraspanin CD37 has recently received renewed interest as a therapeutic target for B-cell
malignancies. Although complement-dependent cytotoxicity (CDC) is a powerful Fc …