Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify
preclinical individuals and target potentially disease-modifying therapies towards them …

G protein-coupled receptors (GPCRs) are the largest family of membrane proteins in the
human body and are responsible for accurately transmitting extracellular information to cells …

Therapeutic options for Alzheimer's disease are limited. Dual compounds targeting two
pathways concurrently may enable enhanced effect. The study focuses on tacrine …

Hippocampal and basal forebrain (BF) atrophy is associated with allocentric navigation
impairment in Alzheimer's disease (AD) and may lead to recruitment of compensatory …

The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk
Alzheimers disease (AD). We aimed to determine their test-retest reliability in a preclinical …

This study was designed to investigate whether Petroselinum crispum (PC) extract has
protective effects on the brain in the scopolamine-induced Alzheimer's disease (AD) rat …

Aim: Galantamine is an acetylcholinesterase inhibitor frequently used in Alzheimer's disease
management. Its cholinergic adverse effects and rapid elimination limit its therapeutic …

Muscarinic acetylcholine receptors (mAChRs) have been found to regulate many diverse
functions, ranging from motivation and feeding to spatial navigation, an important and widely …

Numerous experimental studies suggest the potential for resveratrol (RVT) to be useful in
the Alzheimer's disease treatment, but its low bioavailability limits its application. This study …

Petitgrain essential oil (PGEO) is derived from the water distillation process on mandarin
(Citrus reticulata) leaves. The chemical constituents of PGEO were analyzed by gas …