The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

[HTML][HTML] Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders

SB Sartori, N Singewald - Pharmacology & therapeutics, 2019 - Elsevier
Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential

CD Walker, KG Bath, M Joels, A Korosi, M Larauche… - Stress, 2017 - Taylor & Francis
The immediate and long-term effects of exposure to early life stress (ELS) have been
documented in humans and animal models. Even relatively brief periods of stress during the …

Gut-brain axis: A cutting-edge approach to target neurological disorders and potential synbiotic application

S Ashique, S Mohanto, MG Ahmed, N Mishra, A Garg… - Heliyon, 2024 - cell.com
The microbiota-gut-brain axis (MGBA) represents a sophisticated communication network
between the brain and the gut, involving immunological, endocrinological, and neural …

Small intestinal bacterial overgrowth and irritable bowel syndrome–an update

W Takakura, M Pimentel - Frontiers in psychiatry, 2020 - frontiersin.org
Small intestinal bacterial overgrowth (SIBO) is one manifestation of gut microbiome
dysbiosis and is highly prevalent in IBS (Irritable Bowel Syndrome). SIBO can be diagnosed …

Stress and the microbiota–gut–brain axis in visceral pain: relevance to irritable bowel syndrome

RD Moloney, AC Johnson… - CNS neuroscience & …, 2016 - Wiley Online Library
Visceral pain is a global term used to describe pain originating from the internal organs of
the body, which affects a significant proportion of the population and is a common feature of …

Psychological stress in early life as a predisposing factor for the development of chronic pain: clinical and preclinical evidence and neurobiological mechanisms

NN Burke, DP Finn, BE McGuire… - Journal of neuroscience …, 2017 - Wiley Online Library
A wealth of research over the past 2 decades has expanded our understanding of the impact
of early‐life adversity on physiological function and, consequently, health and wellbeing in …

Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner

E Jašarević, CD Howard, AM Misic, DP Beiting… - Scientific Reports, 2017 - nature.com
The microbiome is a regulator of host immunity, metabolism, neurodevelopment, and
behavior. During early life, bacterial communities within maternal gut and vaginal …

The role of the endocannabinoid system in the brain–gut axis

KA Sharkey, JW Wiley - Gastroenterology, 2016 - Elsevier
The actions of cannabis are mediated by receptors that are part of an endogenous
cannabinoid system. The endocannabinoid system (ECS) consists of the naturally occurring …

[HTML][HTML] Epigenetics of childhood trauma: Long term sequelae and potential for treatment

KM Thumfart, A Jawaid, K Bright, M Flachsmann… - Neuroscience & …, 2022 - Elsevier
Childhood trauma (CT) can have persistent effects on the brain and is one of the major risk
factors for neuropsychiatric diseases in adulthood. Recent advances in the field of …