Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease
worldwide. It is closely related to obesity, insulin resistance (IR) and dyslipidemia so much …

Platelets are one of the key mediators in thrombosis as well as in the progression of many
diseases. An increase in platelet activation and a decrease in platelet count is associated …

Lysosomal acid lipase (LAL) is the sole lysosomal enzyme responsible for the degradation
of cholesteryl esters and triacylglycerols at acidic pH. Impaired LAL activity leads to LAL …

Lysosomes have a central role in the disposal of extracellular and intracellular cargo and
also function as metabolic sensors and signalling platforms in the immunometabolic …

Obesity and type 2 diabetes are frequently complicated by excess fat accumulation in the
liver, which is known as nonalcoholic fatty liver disease (NAFLD). In this context, liver …

Non-alcoholic fatty liver disease (NAFLD), characterized by the accumulation of excessive
intrahepatic fat, is a leading metabolic disorder also considered as the hepatic manifestation …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver
pathology worldwide, closely associated with obesity and metabolic disorders. Increasing …

Lysosomal acid lipase deficiency (LAL-D) is caused by mutations in the LIPA gene, which
encodes the lysosomal enzyme that hydrolyzes triglycerides and cholesteryl esters to free …

Lysosomal acid lipase (LAL), encoded by the gene LIPA, is the sole neutral lipid hydrolase
in lysosomes, responsible for cleavage of cholesteryl esters and triglycerides into their …

Nonalcoholic fatty liver disease (NAFLD) is usually correlated with metabolic diseases, such
as obesity, insulin resistance, and hyperglycemia. Herein, we investigated the inhibitory …