In recent decades, the mechanism underlying bone metabolic disorders based on energy
metabolism has been heavily researched. Bone resorption by osteoclasts plays an important …

The key hallmark of stem cells is their ability to self-renew while kee** a differentiation
potential. Intrinsic and extrinsic cell factors may contribute to a decline in these stem cell …

Abstract Characterization of how the microenvironment, or niche, regulates stem cell activity
is central to understanding stem cell biology and to develo** strategies for the therapeutic …

The defining hallmark of stem cells is their ability to self-renew and maintain multipotency.
This capacity depends on the balance of complex signals in their microenvironment. Low …

Tissue homeostasis over the life of an organism relies on both self-renewal and multipotent
differentiation of stem cells. Hematopoietic stem cells (HSCs) reside in a hypoxic bone …

Tissue engineering has promising prospects for cartilage regeneration. However, there
remains an urgent need to harvest high quality seed cells. Bone marrow mesenchymal cells …

Bone marrow transplantation is the primary therapy for numerous hematopoietic disorders.
The efficiency of bone marrow transplantation depends on the function of long-term …

The emergence of tissue engineering raises new possibilities for the study of complex
physiological and pathophysiological processes in vitro. Many tools are now available to …

Antiangiogenic therapy has been thought to hold significant potential for the treatment of
cancer. However, the efficacy of such treatments, especially in breast cancer patients, has …

The importance of the vascular supply for bone is well-known to orthopaedists but is still
rather overlooked within the wider field of skeletal research. Blood supplies oxygen …