Mechanisms, regulation and functions of the unfolded protein response
Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …
ER stress and the unfolded protein response in neurodegeneration
The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …
alteration in the functionality of distinct neuronal populations. The pathology of many …
Impaired insulin signalling and allostatic load in Alzheimer disease
The discovery of insulin in 1921 revolutionized the treatment of diabetes and paved the way
for numerous studies on hormone signalling networks and actions in peripheral tissues and …
for numerous studies on hormone signalling networks and actions in peripheral tissues and …
ER stress and UPR in Alzheimer's disease: mechanisms, pathogenesis, treatments
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
gradual loss of memory and cognitive function, which constitutes a heavy burden on the …
gradual loss of memory and cognitive function, which constitutes a heavy burden on the …
Endoplasmic reticulum stress and unfolded protein response in neurodegenerative diseases
The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …
Roles of XBP1s in transcriptional regulation of target genes
SM Park, TI Kang, JS So - Biomedicines, 2021 - mdpi.com
The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that
plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) …
plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) …
Insulin resistance and diabetes mellitus in Alzheimer's disease
Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …
insulin resistance. The term insulin resistance is very wide and could affect different proteins …
Homeostasis control in health and disease by the unfolded protein response
Cells rely on the endoplasmic reticulum (ER) to fold and assemble newly synthesized
transmembrane and secretory proteins—essential for cellular structure–function and for both …
transmembrane and secretory proteins—essential for cellular structure–function and for both …
Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease
Y Gerakis, C Hetz - The FEBS journal, 2018 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
synaptic dysfunction and accumulation of abnormal aggregates formed by amyloid‐β …
synaptic dysfunction and accumulation of abnormal aggregates formed by amyloid‐β …
[HTML][HTML] Identification of therapeutic targets for amyotrophic lateral sclerosis using PandaOmics–an AI-enabled biological target discovery platform
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with ill-defined
pathogenesis, calling for urgent developments of new therapeutic regimens. Herein, we …
pathogenesis, calling for urgent developments of new therapeutic regimens. Herein, we …