Pyroptosis: mechanisms and diseases

P Yu, X Zhang, N Liu, L Tang, C Peng… - Signal transduction and …, 2021 - nature.com
Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

[PDF][PDF] Epidemiology of hepatocellular carcinoma

KA McGlynn, JL Petrick, HB El‐Serag - Hepatology, 2021 - Wiley Online Library
Liver cancer is a major contributor to the worldwide cancer burden. Incidence rates of this
disease have increased in many countries in recent decades. As the principal histologic type …

Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer

DQ Huang, AG Singal, Y Kono, DJH Tan, HB El-Serag… - Cell metabolism, 2022 - cell.com
Liver cancer epidemiology is changing due to increasing alcohol consumption, rising
prevalence of obesity, and advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) …

Hepatocellular carcinoma immunotherapy

RC Sperandio, RC Pestana… - Annual review of …, 2022 - annualreviews.org
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and the third
leading cause of cancer-related death worldwide. Single-agent anti-PD-1 immune …

Epidemiology and management of hepatocellular carcinoma

L Kulik, HB El-Serag - Gastroenterology, 2019 - Elsevier
The major risk factors for hepatocellular carcinoma (HCC) in contemporary clinical practice
are becoming increasingly related to sustained virological response after hepatitis C …

Mechanisms of liver fibrosis and its role in liver cancer

D Dhar, J Baglieri, T Kisseleva… - … Biology and Medicine, 2020 - journals.sagepub.com
Hepatic fibrogenesis is a pathophysiological outcome of chronic liver injury hallmarked by
excessive accumulation of extracellular matrix proteins. Fibrosis is a dynamic process that …

Liver cancer cell of origin, molecular class, and effects on patient prognosis

D Sia, A Villanueva, SL Friedman, JM Llovet - Gastroenterology, 2017 - Elsevier
Primary liver cancer is the second leading cause of cancer-related death worldwide and
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …

Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

N Fujiwara, SL Friedman, N Goossens, Y Hoshida - Journal of hepatology, 2018 - Elsevier
Patients who develop chronic fibrotic liver disease, caused by viral or metabolic aetiologies,
are at a high risk of develo** hepatocellular carcinoma (HCC). Even after complete HCC …

Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

Y Zhou, H Ren, B Dai, J Li, L Shang, J Huang… - Journal of Experimental & …, 2018 - Springer
Background Hepatocellular carcinoma (HCC) remains a global challenge due to its high
morbidity and mortality rates as well as poor response to treatment. The communication …

Hepatocellular Carcinoma (HCC) in Egypt: A comprehensive overview

WM Rashed, MAM Kandeil, MO Mahmoud… - Journal of the Egyptian …, 2020 - Springer
Background Worldwide, hepatocellular carcinoma (HCC) is a universal problem and its
epidemiological data showed variation from place to place. Hepatocellular carcinoma (HCC) …