Role of turmeric and curcumin in prevention and treatment of chronic diseases: Lessons learned from clinical trials

AB Kunnumakkara, M Hegde, D Parama… - ACS pharmacology & …, 2023 - ACS Publications
Turmeric (Curcuma longa) has been used for thousands of years for the prevention and
treatment of various chronic diseases. Curcumin is just one of> 200 ingredients in turmeric …

[HTML][HTML] Renoprotective effect of the antioxidant curcumin: Recent findings

J Trujillo, YI Chirino, E Molina-Jijón… - Redox biology, 2013 - Elsevier
For years, there have been studies based on the use of natural compounds plant-derived as
potential therapeutic agents for various diseases in humans. Curcumin is a phenolic …

Therapeutic potential of curcumin in diabetic complications

N Parsamanesh, M Moossavi, A Bahrami… - Pharmacological …, 2018 - Elsevier
Diabetes mellitus is an extremely prevalent endocrine disease and a major global public
health concern. Diabetic complications, such as retinopathy, nephropathy, neuropathy and …

[HTML][HTML] Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

M Matzinger, K Fischhuber, EH Heiss - Biotechnology advances, 2018 - Elsevier
Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …

Advanced glycation end products mediated cellular and molecular events in the pathology of diabetic nephropathy

A Kumar Pasupulati, PS Chitra, GB Reddy - Biomolecular concepts, 2016 - degruyter.com
Diabetic nephropathy (DN) is a major cause of morbidity and mortality in diabetic patients
and a leading cause of end-stage renal disease (ESRD). Degenerative changes such as …

Anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin

Z Ghorbani, A Hekmatdoost… - International journal of …, 2014 - pmc.ncbi.nlm.nih.gov
Context: Turmeric is obtained from the plant Curcuma longa L; its major constituent,
curcumin, is a polyphenol with multiple effects which can modulate some signaling …

Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-κB both in vitro and in vivo

C Zeng, P Zhong, Y Zhao, K Kanchana, Y Zhang… - Journal of molecular and …, 2015 - Elsevier
Obesity and increased free fatty acid (FFA) level are tightly linked, leading to the
development of cardiovascular disorders. Curcumin is a natural product from Curcuma …

Effect of redox modulating NRF2 activators on chronic kidney disease

B Choi, KS Kang, MK Kwak - Molecules, 2014 - mdpi.com
Chronic kidney disease (CKD) is featured by a progressive decline of kidney function and is
mainly caused by chronic diseases such as diabetes mellitus and hypertension. CKD is a …

Protective effects of curcumin on renal oxidative stress and lipid metabolism in a rat model of type 2 diabetic nephropathy

BH Kim, ES Lee, R Choi, J Nawaboot… - Yonsei medical …, 2016 - synapse.koreamed.org
Purpose Diabetic nephropathy is a serious complication of type 2 diabetes mellitus, and
delaying the development of diabetic nephropathy in patients with diabetes mellitus is very …