Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Vitamin B 12, cobalamin, is a cobalt-containing ring-contracted modified tetrapyrrole that
represents one of the most complex small molecules made by nature. In prokaryotes it is …

Zinc (Zn) is an essential micronutrient and cofactor for up to 10% of proteins in living
organisms. During Zn limitation, specialized enzymes called metallochaperones are …

Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …

Zinc (Zn) is an essential metal that vertebrates sequester from pathogens to protect against
infection. Investigating the opportunistic pathogen Acinetobacter baumannii's response to Zn …

Bacterial transition metal homoeostasis or simply 'metallostasis' describes the process by
which cells control the intracellular availability of functionally required metal cofactors, from …

Protein metal-occupancy (metalation) in vivo has been elusive. To address this challenge,
the available free energies of metals have recently been determined from the responses of …

Highlights•The 'fight over copper and zinc'at the host–pathogen interface is
discussed.•Proteins involved in copper and zinc trafficking and sensing are …

Zinc is an essential cofactor required for life and, as such, mechanisms exist for its
homeostatic maintenance in biological systems. Despite the evolutionary distance between …

Between 5 and 10% of all proteins of a given organism are estimated to require zinc for
function, and hence zinc is essential for almost any given metabolic process. It is therefore of …