DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity.
Failure to repair a DSB has deleterious consequences, including genomic instability and cell …

Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

Brca2 deficiency causes Mre11-dependent degradation of nascent DNA at stalled forks,
leading to cell lethality. To understand the molecular mechanisms underlying this process …

The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and
BRCA2, work in a common pathway of genome protection. However, the two proteins work …

Breast cancer suppressor BRCA2 is critical for maintenance of genomic integrity and
resistance to agents that damage DNA or collapse replication forks, presumably through …

Reversion mutations in BRCA1 or BRCA2 are associated with resistance to PARP inhibitors
and platinum. To better understand the nature of these mutations, we collated, codified, and …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

Mitotic homologous recombination promotes genome stability through the precise repair of
DNA double-strand breaks and other lesions that are encountered during normal cellular …

Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-
stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the …

Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …