The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

For both the atria and ventricles, fibrosis is generally recognized as one of the key
determinants of conduction disturbances. By definition, fibrosis refers to an increased …

Aims The concept of “atrial cardiomyopathy”(AtCM) had been percolating through the
literature since its first mention in 1972. Since then, publications using the term were …

Background Endocardial catheter ablation (CA) has limited long-term benefit for persistent
and longstanding persistent atrial fibrillation (PersAF/LSPAF). We hypothesized hybrid …

Atrial fibrillation (AF) contributes to morbidity and mortality of millions of individuals. Its
molecular, cellular, neurohumoral, and hemodynamic pathophysiological mechanisms are …

We propose FiberNet, a method to estimate in-vivo the cardiac fiber architecture of the
human atria from multiple catheter recordings of the electrical activation. Cardiac fibers play …

Stroke is a leading cause of death worldwide. With escalating healthcare costs, early non-
invasive stroke risk stratification is vital. The current paradigm of stroke risk assessment and …

Aims Although in persistent atrial fibrillation (AF) a complex AF substrate characterized by a
high incidence of conduction block has been reported, relatively little is known about AF …

Aims Intramural fibrosis represents a crucial factor in the formation of a three-dimensional
(3D) substrate for atrial fibrillation (AF). However, the transmural distribution of fibrosis and …

A key component in develo** atrial digital twins (ADT)-virtual representations of patients'
atria—is the accurate prescription of myocardial fibers which are essential for the tissue …