New insights and potential therapeutic targeting of CB2 cannabinoid receptors in CNS disorders

BG Kibret, H Ishiguro, Y Horiuchi, ES Onaivi - International journal of …, 2022 - mdpi.com
The endocannabinoid system (ECS) is ubiquitous in most human tissues, and involved in
the regulation of mental health. Consequently, its dysregulation is associated with …

Cannabinoid treatments in epilepsy and seizure disorders

O Devinsky, NA Jones, MO Cunningham… - Physiological …, 2024 - journals.physiology.org
Cannabis has been used to treat convulsions and other disorders since ancient times. In the
last few decades, preclinical animal studies and clinical investigations have established the …

Potential role of cannabinoid type 2 receptors in neuropsychiatric and neurodegenerative disorders

H Ishiguro, BG Kibret, Y Horiuchi, ES Onaivi - Frontiers in Psychiatry, 2022 - frontiersin.org
The endocannabinoid system (ECS) is composed of the two canonical receptor subtypes;
type-1 cannabinoid (CB1R) and type 2 receptor (CB2R), endocannabinoids (eCBs) and …

Pharmacokinetic and tissue distribution study of eight volatile constituents in rats orally administrated with the essential oil of Artemisiae argyi Folium by GC–MS/MS

MZ Hou, LL Chen, C Chang, JF Zan, SM Du - Journal of Chromatography B, 2021 - Elsevier
Artemisia argyi is commonly used as a remedy for gynecological and respiratory disease in
traditional Chinese medicine. The essential oil is considered as the major active ingredients …

[HTML][HTML] On the application of 3d metals for C–H activation toward bioactive compounds: The key step for the synthesis of silver bullets

RL Carvalho, AS de Miranda… - Beilstein Journal of …, 2021 - beilstein-journals.org
Several valuable biologically active molecules can be obtained through C–H activation
processes. However, the use of expensive and not readily accessible catalysts complicates …

Cannabidiol and beta-caryophyllene in combination: a therapeutic functional interaction

H Blanton, L Yin, J Duong, K Benamar - International Journal of …, 2022 - mdpi.com
Cannabis contains over 500 distinct compounds, which include cannabinoids, terpenoids,
and flavonoids. However, very few of these compounds have been studied for their …

The CB2 Receptor as a Novel Therapeutic Target for Epilepsy Treatment

X Ji, Y Zeng, J Wu - International Journal of Molecular Sciences, 2021 - mdpi.com
Epilepsy is characterized by repeated spontaneous bursts of neuronal hyperactivity and
high synchronization in the central nervous system. It seriously affects the quality of life of …

β-caryophyllene cationic nanoemulsion for intranasal delivery and treatment of epilepsy: development and in vivo evaluation of anticonvulsant activity

C Nogueira, E Lemos-Senna, E da Silva Vieira… - Journal of Nanoparticle …, 2023 - Springer
Intranasal delivery systems have been proposed as alternative routes for drug delivery to the
brain, primarily for treating diseases that affect the central nervous system. β-Caryophyllene …

Bridging the gap: The endocannabinoid system as a functional fulcrum for benzodiazepines in a novel frontier of anxiety pharmacotherapy

S Pakkhesal, M Shakouri, R Mosaddeghi-Heris… - Pharmacology & …, 2025 - Elsevier
While benzodiazepines have been a mainstay of the pharmacotherapy of anxiety disorders,
their short-term efficacy and risk of abuse have driven the exploration of alternative treatment …

Plant based food bioactives: A boon or bane for neurological disorders

N Choudhary, D Tewari, SF Nabavi… - Critical Reviews in …, 2024 - Taylor & Francis
Neurological disorders are the foremost occurring diseases across the globe resulting in
progressive dysfunction, loss of neuronal structure ultimately cell death. Therefore, attention …