Abstract Polo-like kinase 1 (Plk1) overexpression has been shown to occur in a wide range
of tumors, prompting research and development of Plk1 inhibitors as a means of cancer …

Polo-like kinases (Plks) are a family of serine-threonine kinases that regulate multiple
intracellular processes including DNA replication, mitosis, and stress response. Plk1, the …

Disassembly of nuclear pore complexes (NPCs) is a decisive event during mitotic entry in
cells undergoing open mitosis, yet the molecular mechanisms underlying NPC disassembly …

Centrosomes are closely associated with the nuclear envelope (NE) throughout the cell
cycle and this association is maintained in prophase when they separate to establish the …

Inhibitors of mitotic protein kinases are currently being developed as non-neurotoxic
alternatives of microtubule-targeting agents (taxanes, vinca alkaloids) which provide a …

Elucidating mechanisms of hepatitis B virus (HBV)–mediated hepatocarcinogenesis is
needed to gain insights into the etiology and treatment of liver cancer. Cells where HBV is …

During interphase, the nuclear envelope (NE) serves as a selective barrier between cytosol
and nucleoplasm. When vertebrate cells enter mitosis, the NE is dismantled in the process of …

ABSTRACT Introduction Polo Like Kinase 1 (PLK1) is a key regulator of mitosis and its
overexpression is frequently observed in a wide variety of human cancers, while often being …

Polo-like kinase 1 (PLK1) is a key regulator of eukaryotic cell division. During mitosis,
dynamic regulation of PLK1 is crucial for its roles in centrosome maturation, spindle …

Prostate cancer is thought to be driven by oxidative stress, lipid metabolism, androgen
receptor (AR) signaling, and activation of the PI3K–AKT–mTOR pathway, but it is uncertain …