As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

INTRODUCTION Human beings are equipped with multiple senses (sight, hearing, smell,
taste, touch, and proprioception) to help them to react properly to their environment. The …

INTRODUCTION The human body is a crowded place. This crowding is even more acute
when the regulation of cell growth and proliferation fails during the formation of a tumor …

ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous
genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs …

YAP/TAZ is a master regulator of mechanotransduction whose functions rely on
translocation from the cytoplasm to the nucleus in response to diverse physical cues …

Tissue-scale architecture and mechanical properties instruct cell behaviour under
physiological and diseased conditions, but our understanding of the underlying mechanisms …

Actin plays roles in many important cellular processes, including cell motility, organelle
movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the …

The nuclear lamina (NL) is a crucial component of the inner nuclear membrane (INM) and
consists of lamin filaments and associated proteins. Lamins are type V intermediate filament …

The cell nucleus is best known as the container of the genome. Its envelope provides a
barrier for passive macromolecule diffusion, which enhances the control of gene expression …