Advances in graft-versus-host disease biology and therapy
Allogeneic haematopoietic stem cell transplantation is used to treat a variety of disorders,
but its efficacy is limited by the occurrence of graft-versus-host disease (GVHD). The past …
but its efficacy is limited by the occurrence of graft-versus-host disease (GVHD). The past …
[HTML][HTML] Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies
Abstract Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of
intensive research because of its crucial role in the pathogenesis of different diseases …
intensive research because of its crucial role in the pathogenesis of different diseases …
[HTML][HTML] The biology of chronic graft-versus-host disease: a task force report from the National Institutes of Health Consensus Development Project on Criteria for …
Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality
and disability in allogeneic hematopoietic cell transplantation recipients and a major …
and disability in allogeneic hematopoietic cell transplantation recipients and a major …
Current concepts and advances in graft-versus-host disease immunology
Worldwide, each year over 30,000 patients undergo an allogeneic hema-topoietic stem cell
transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency …
transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency …
The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin
CT Weaver, CO Elson, LA Fouser… - Annual Review of …, 2013 - annualreviews.org
The recent discovery of a new CD4+ T cell subset, Th17, has transformed our understanding
of the pathogenetic basis of an increasing number of chronic immune-mediated diseases …
of the pathogenetic basis of an increasing number of chronic immune-mediated diseases …
Chronic graft-versus-host disease: biological insights from preclinical and clinical studies
KPA MacDonald, GR Hill… - Blood, The Journal of the …, 2017 - ashpublications.org
With the increasing use of mismatched, unrelated, and granulocyte colony-stimulating factor–
mobilized peripheral blood stem cell donor grafts and successful treatment of older …
mobilized peripheral blood stem cell donor grafts and successful treatment of older …
Th17 cells are long lived and retain a stem cell-like molecular signature
Th17 cells have been described as short lived, but this view is at odds with their capacity to
trigger protracted damage to normal and transformed tissues. We report that Th17 cells …
trigger protracted damage to normal and transformed tissues. We report that Th17 cells …
Essentials of Th17 cell commitment and plasticity
Abstract CD4+ T helper (Th) cells exist in a variety of epigenetic states that determine their
function, phenotype, and capacity for persistence. These polarization states include Th1 …
function, phenotype, and capacity for persistence. These polarization states include Th1 …
T cell subsets in graft versus host disease and graft versus tumor
Allogeneic hematopoietic cell transplantation (allo-HCT) is an essential therapeutic modality
for patients with hematological malignancies and other blood disorders. Unfortunately, acute …
for patients with hematological malignancies and other blood disorders. Unfortunately, acute …
The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease
Hematopoietic cell transplantation (HCT) is a critical treatment of patients with high-risk
hematopoietic malignancies, hematological deficiencies, and other immune diseases. In …
hematopoietic malignancies, hematological deficiencies, and other immune diseases. In …