BACKGROUND Mammalian germ cells differentiate into oocytes in females and
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …

Steroidogenic factor-1 (SF-1, also termed Ad4BP; NR5A1 in the official nomenclature) is a
nuclear receptor transcription factor that plays a crucial role in the regulation of adrenal and …

An in vitro model of human ovarian follicles would greatly benefit the study of female
reproduction. Ovarian development requires the combination of germ cells and several …

In vitro oogenesis is key to elucidating the mechanism of human female germ‐cell
development and its anomalies. Accordingly, pluripotent stem cells have been induced into …

Development of the adrenal cortex, a vital endocrine organ, originates in the adrenogonadal
primordium, a common progenitor for both the adrenocortical and gonadal lineages in …

Recent regenerative studies using human pluripotent stem cells (hPSCs) have developed
multiple kidney-lineage cells and organoids. However, to further form functional segments of …

The mechanisms leading to adrenal cortex development and steroid synthesis in humans
remain poorly understood due to the paucity of model systems. Herein, we recapitulate …

Differentiation of the bipotential gonadal primordium into ovaries and testes is a common
process among vertebrate species. While vertebrate ovaries eventually share the same …

The cortex of the adrenal gland is organized into concentric zones that produce distinct
steroid hormones essential for body homeostasis in mammals. Mechanisms leading to the …

Nuclear receptor subfamily 5 group A member 1 (NR5A1) encodes steroidogenic factor 1
(SF1), a key regulatory factor that determines gonadal development and coordinates …