New insights into activation and function of the AMPK
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
AMP-activated protein kinase: the current landscape for drug development
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …
homeostasis, many exciting insights into its structure, regulation and physiological roles …
AMPK: an energy-sensing pathway with multiple inputs and outputs
AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …
AMPK as a therapeutic target for treating metabolic diseases
The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
The obesity epidemic has led to an increased incidence of nonalcoholic fatty liver disease
(NAFLD) and type 2 diabetes. AMP-activated protein kinase (Ampk) regulates energy …
(NAFLD) and type 2 diabetes. AMP-activated protein kinase (Ampk) regulates energy …
AMPK and the adaptation to exercise
HR Spaulding, Z Yan - Annual review of physiology, 2022 - annualreviews.org
Noncommunicable diseases are chronic diseases that contribute to death worldwide, but
these diseases can be prevented and mitigated with regular exercise. Exercise activates …
these diseases can be prevented and mitigated with regular exercise. Exercise activates …
[HTML][HTML] AMPK in skeletal muscle function and metabolism
Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …
AMPK activators: mechanisms of action and physiological activities
J Kim, G Yang, Y Kim, J Kim, J Ha - Experimental & molecular medicine, 2016 - nature.com
AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which
coordinates metabolic pathways and thus balances nutrient supply with energy demand …
coordinates metabolic pathways and thus balances nutrient supply with energy demand …
Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis
Abstract Mitochondrial uncoupling protein 1 (UCP1) is enriched within interscapular brown
adipose tissue (iBAT) and beige (also known as brite) adipose tissue,, but its thermogenic …
adipose tissue (iBAT) and beige (also known as brite) adipose tissue,, but its thermogenic …
[HTML][HTML] Sarcopenia and muscle aging: a brief overview
The world is facing the new challenges of an aging population, and understanding the
process of aging has therefore become one of the most important global concerns …
process of aging has therefore become one of the most important global concerns …