Dysregulated ribosome quality control in human diseases
Precise regulation of mRNA translation is of fundamental importance for maintaining
homeostasis. Conversely, dysregulated general or transcript‐specific translation, as well as …
homeostasis. Conversely, dysregulated general or transcript‐specific translation, as well as …
SARS-CoV-2 Nsp1 mediated mRNA degradation requires mRNA interaction with the ribosome
SI Shehata, R Parker - RNA biology, 2023 - Taylor & Francis
Nsp1 is a SARS-CoV-2 host shutoff factor that both represses cellular translation and
promotes host RNA decay. However, it is unclear how these two activities are connected …
promotes host RNA decay. However, it is unclear how these two activities are connected …
FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration
B Szewczyk, R Günther, J Japtok, MJ Frech… - Cell Reports, 2023 - cell.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder causing progressive
loss of motor neurons. Mutations in Fused in sarcoma (FUS) leading to its cytoplasmic …
loss of motor neurons. Mutations in Fused in sarcoma (FUS) leading to its cytoplasmic …
Run, Ribosome, Run: From compromised translation to human health
Significance: Translation is an essential cellular process, and diverse signaling pathways
have evolved to deal with problems arising during translation. Erroneous stalls and …
have evolved to deal with problems arising during translation. Erroneous stalls and …
Nsp1 facilitates SARS-CoV-2 replication through calcineurin-NFAT signaling
ABSTRACT SARS-CoV-2, the causative agent of COVID-19, has been intensely studied in
search of effective antiviral treatments. The immunosuppressant cyclosporine A (CsA) has …
search of effective antiviral treatments. The immunosuppressant cyclosporine A (CsA) has …
Eight-amino-acid sequence at the N-terminus of SARS-CoV-2 nsp1 is involved in stabilizing viral genome replication
S Ueno, S Amarbayasgalan, Y Sugiura, T Takahashi… - Virology, 2024 - Elsevier
Coronavirus disease 19 is caused by severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) enveloped virus with a single-stranded positive-sense ribonucleic acid …
(SARS-CoV-2) enveloped virus with a single-stranded positive-sense ribonucleic acid …
Ribosome stalling during c-myc translation presents actionable cancer cell vulnerability
Myc is a major driver of tumor initiation, progression, and maintenance. Up-regulation of Myc
protein level rather than acquisition of neomorphic properties appears to underlie most Myc …
protein level rather than acquisition of neomorphic properties appears to underlie most Myc …
The relationship between Ribosome-associated Quality Control and neurological disorders
J Wang, J Wang, H Cao, Y **ng, Z Wang… - The Journals of …, 2024 - academic.oup.com
Ribosome-associated quality control (RQC), a ubiquitous process essential for maintaining
protein homeostasis in eukaryotes, acts as a critical surveillance system for protein …
protein homeostasis in eukaryotes, acts as a critical surveillance system for protein …
COVID‐19 and cognitive impairment: From evidence to SARS‐CoV‐2 mechanism
H Pan, J Niu, L Feng, Y Yin, C Dang, Y Lu, L Li, J Ji… - Brain‐X, 2024 - Wiley Online Library
Caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), coronavirus
disease 2019 (COVID‐19) primarily manifests as respiratory dysfunction. However …
disease 2019 (COVID‐19) primarily manifests as respiratory dysfunction. However …
Uncoupling the functional roles of Coronavirus Nsp1
E Bäumlin, D Andenmatten, J Luginbühl, A Lalou… - bioRxiv, 2024 - biorxiv.org
The emergence of pathogenic coronaviruses has highlighted the interplay between viral
components and host gene expression during infection. Non-structural protein 1 (Nsp1), the …
components and host gene expression during infection. Non-structural protein 1 (Nsp1), the …