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Radical causes of cancer
SP Hussain, LJ Hofseth, CC Harris - Nature Reviews Cancer, 2003 - nature.com
Free radicals are ubiquitous in our body and are generated by normal physiological
processes, including aerobic metabolism and inflammatory responses, to eliminate invading …
processes, including aerobic metabolism and inflammatory responses, to eliminate invading …
Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesis
D Kremsdorf, P Soussan, P Paterlini-Brechot… - Oncogene, 2006 - nature.com
As discussed in detail in other chapters of this review, chronic hepatitis B (HBV) infection is a
major risk factor for hepatocellular carcinoma (HCC). Most HCCs complicate the evolution of …
major risk factor for hepatocellular carcinoma (HCC). Most HCCs complicate the evolution of …
Hepatitis B virus X protein promotes liver cell pyroptosis under oxidative stress through NLRP3 inflammasome activation
W **e, J Ding, X **e, X Yang, XF Wu, Z Chen… - Inflammation …, 2020 - Springer
Abstract Objective Hepatitis B virus X protein (HBx) is a pivotal factor for HBV-induced
hepatitis. Herein, we sought to investigate HBx-mediated NLR pyrin domain containing 3 …
hepatitis. Herein, we sought to investigate HBx-mediated NLR pyrin domain containing 3 …
Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARγ
KH Kim, HJ Shin, K Kim, HM Choi, SH Rhee, HB Moon… - Gastroenterology, 2007 - Elsevier
Background & Aims: Hepatic steatosis occurs frequently in patients with chronic hepatitis B
virus (HBV) or chronic hepatitis C virus (HCV) infection. Recently, several studies suggested …
virus (HBV) or chronic hepatitis C virus (HCV) infection. Recently, several studies suggested …
Hepatitis B virus X gene and hepatocarcinogenesis
Chronic hepatitis B virus (HBV) infection has been identified as a major risk factor in
hepatocellular carcinoma (HCC), which is one of the most common cancers worldwide. The …
hepatocellular carcinoma (HCC), which is one of the most common cancers worldwide. The …
[HTML][HTML] Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1α through activation of mitogen-activated protein kinase pathway
Hepatitis B virus X protein (HBx) of the hepatitis B virus was strongly implicated in
angiogenesis and metastasis during hepatocarcinogenesis. Here, we explored the …
angiogenesis and metastasis during hepatocarcinogenesis. Here, we explored the …
Hepatocellular carcinoma: the point of view of the hepatitis B virus
T Pollicino, C Saitta, G Raimondo - Carcinogenesis, 2011 - academic.oup.com
Hepatitis B virus (HBV) infection is the main risk factor for hepatocellular carcinoma (HCC)
development, as suggested by many epidemiological and molecular studies (1–13) and as …
development, as suggested by many epidemiological and molecular studies (1–13) and as …
The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma
P Yang, GJ Markowitz, XF Wang - National science review, 2014 - academic.oup.com
In contrast to a majority of cancer types, the initiation of hepatocellular carcinoma (HCC) is
intimately associated with a chronically diseased liver tissue, with one of the most prevalent …
intimately associated with a chronically diseased liver tissue, with one of the most prevalent …
[HTML][HTML] Mechanisms of hepatocellular injury in hepatitis A
Hepatitis A virus (HAV) infection is a common cause of acute viral hepatitis worldwide.
Despite decades of research, the pathogenic mechanisms of hepatitis A remain …
Despite decades of research, the pathogenic mechanisms of hepatitis A remain …
Inflammation-dependent IL18 signaling restricts hepatocellular carcinoma growth by enhancing the accumulation and activity of tumor-infiltrating lymphocytes
GJ Markowitz, P Yang, J Fu, GA Michelotti… - Cancer …, 2016 - aacrjournals.org
Chronic inflammation in liver tissue is an underlying cause of hepatocellular carcinoma.
High levels of inflammatory cytokine IL18 in the circulation of patients with hepatocellular …
High levels of inflammatory cytokine IL18 in the circulation of patients with hepatocellular …