[HTML][HTML] Epigenetic alterations in cancer
Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …
Epigenetics in cancer: fundamentals and beyond
S Biswas, CM Rao - Pharmacology & Therapeutics, 2017 - Elsevier
Activation of oncogenes or the deactivation of tumor suppressor genes has long been
established as the fundamental mechanism leading towards carcinogenesis. Although this …
established as the fundamental mechanism leading towards carcinogenesis. Although this …
Circular RNA ciRS-7—a promising prognostic biomarker and a potential therapeutic target in colorectal cancer
Purpose: Colorectal cancer is one of the most common malignancies worldwide. Recently, a
novel circular RNA, ciRS-7, was proposed to be a potential miR-7 sponge. As miR-7, a …
novel circular RNA, ciRS-7, was proposed to be a potential miR-7 sponge. As miR-7, a …
Intranasal delivery of targeted polyfunctional gold–iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and …
UK Sukumar, RJC Bose, M Malhotra, HA Babikir… - Biomaterials, 2019 - Elsevier
The prognosis for glioblastoma (GBM) remains depressingly low. The biological barriers of
the brain present a major challenge to achieving adequate drug concentrations for GBM …
the brain present a major challenge to achieving adequate drug concentrations for GBM …
microRNAs (miRNAs) in glioblastoma multiforme (GBM)—recent literature review
M Makowska, B Smolarz, H Romanowicz - International Journal of …, 2023 - mdpi.com
Glioblastoma multiforme (GBM) is the most common, malignant, poorly promising primary
brain tumor. GBM is characterized by an infiltrating growth nature, abundant vascularization …
brain tumor. GBM is characterized by an infiltrating growth nature, abundant vascularization …
RNA modifications and cancer
ABSTRACT RNA plays essential roles in not only translating nucleic acids into proteins, but
also in gene regulation, environmental interactions and many human diseases. Nature uses …
also in gene regulation, environmental interactions and many human diseases. Nature uses …
Targeting the oncogenic p53 mutants in colorectal cancer and other solid tumors
Colorectal cancer (CRC) is a kind of solid tumor and the third most common cancer type in
the world. It is a heterogeneous disease characterized by genetic and epigenetic …
the world. It is a heterogeneous disease characterized by genetic and epigenetic …
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma
S Tomaselli, F Galeano, S Alon, S Raho, S Galardi… - Genome biology, 2015 - Springer
Background ADAR enzymes convert adenosines to inosines within double-stranded RNAs,
including microRNA (miRNA) precursors, with important consequences on miRNA …
including microRNA (miRNA) precursors, with important consequences on miRNA …
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
B England, T Huang, M Karsy - Tumor Biology, 2013 - Springer
Glioblastoma multiforme (GBM) is the most common primary malignancy in the brain and
confers a uniformly poor prognosis. Despite decades of research on the topic, limited …
confers a uniformly poor prognosis. Despite decades of research on the topic, limited …
[HTML][HTML] Plasma microRNAs predicting clinical outcome in metastatic colorectal cancer patients receiving first-line oxaliplatin-based treatment
The conventional first-line chemotherapy for metastatic colorectal cancer (mCRC) consists of
fluorouracil (5-FU) in combination with either oxaliplatin or irinotecan. We have explored …
fluorouracil (5-FU) in combination with either oxaliplatin or irinotecan. We have explored …