Many important interactions between bacterial pathogens and their hosts are highly specific
binding events that involve host or pathogen carbohydrate structures (glycans). Glycan …

Sialic acids (Sias) are abundant on vertebrate glycoproteins, glycolipids, and milk
oligosaccharides, as well as on some microbial surface glycans, mediating diverse …

Sialic acid (N-acetylneuraminic acid (Neu5Ac)) is commonly found in the terminal location of
colonic mucin glycans where it is a much-coveted nutrient for gut bacteria, including …

Sialic acids are a group of nine-carbon α-keto acids. Sialic acid exists in more than 50 forms,
with the natural types discovered as N-acetylneuraminic acid (Neu5Ac), deaminoneuraminic …

Sialidases are a large group of enzymes, the majority of which catalyses the cleavage of
terminal sialic acids from complex carbohydrates on glycoproteins or glycolipids. In the …

In consequence of their biological effects, conformationally constrained carbocyclic β-amino
acids have generated great interest among synthetic and medicinal chemists in the past 2 …

Affinity labeling of biomacromolecules is vital for bioimaging and functional studies.
However, affinity probes recognizing glycans with high specificity remain scarce. Here we …

Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-
containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation …

Widely distributed in nature, sulfated glycan epitopes play important roles in diverse
pathophysiological processes. However, due to their structural complexity, the preparation of …

Community‐acquired pneumonia (CAP) remains a leading cause of morbidity and mortality
among the infectious diseases. Despite the implementation of national pneumococcal …