Endogenous biomarkers for SLC transporter-mediated drug-drug interaction evaluation
Membrane transporters play an important role in the absorption, distribution, metabolism,
and excretion of xenobiotic substrates, as well as endogenous compounds. The evaluation …
and excretion of xenobiotic substrates, as well as endogenous compounds. The evaluation …
Research methods and new advances in drug–drug interactions mediated by renal transporters
K Lin, X Kong, X Tao, X Zhai, L Lv, D Dong, S Yang… - Molecules, 2023 - mdpi.com
The kidney is critical in the human body's excretion of drugs and their metabolites. Renal
transporters participate in actively secreting substances from the proximal tubular cells and …
transporters participate in actively secreting substances from the proximal tubular cells and …
A Metabolomic Analysis of Sensitivity and Specificity of 23 Previously Proposed Biomarkers for Renal Transporter‐Mediated Drug‐Drug Interactions
A Gessner, F Müller, P Wenisch… - Clinical …, 2023 - Wiley Online Library
Endogenous biomarkers are discussed as tools for detection of drug‐drug interactions
(DDIs) mediated by renal transport proteins, such as organic cation transporter 2 (OCT2) …
(DDIs) mediated by renal transport proteins, such as organic cation transporter 2 (OCT2) …
New Biomarkers for Renal Transporter‐Mediated Drug–Drug Interactions: Metabolomic Effects of Cimetidine, Probenecid, Verapamil, and Rifampin in Humans
The inhibition of renal transport proteins organic cation transporter 2 (OCT2), multidrug and
toxin extrusion proteins (MATE1, MATE2‐K), and organic anion transporters (OAT1, OAT3) …
toxin extrusion proteins (MATE1, MATE2‐K), and organic anion transporters (OAT1, OAT3) …
Quantitative prediction of OATP1B-mediated drug–drug interactions using endogenous biomarker coproporphyrin I
H Takubo, K Bessho, R Watari, R Shigemi - Xenobiotica, 2022 - Taylor & Francis
Abstract Evaluation of the organic anion transporting polypeptide (OATP) 1B-mediated drug–
drug interaction (DDI) potential is important for drug development. The focus of this study …
drug interaction (DDI) potential is important for drug development. The focus of this study …
Metabolism, Disposition, Excretion, and Potential Transporter Inhibition of 7–16, an Improving 5-HT2A Receptor Antagonist and Inverse Agonist for Parkinson's …
Z Hu, W Wang, H Yang, F Zhao, C Sha, W Mi, S Yin… - Molecules, 2024 - mdpi.com
Compound 7–16 was designed and synthesized in our previous study and was identified as
a more potential selective 5-HT2A receptor antagonist and inverse agonist for treating …
a more potential selective 5-HT2A receptor antagonist and inverse agonist for treating …
Dicloxacillin is an inducer of intestinal P‐glycoprotein but neither dicloxacillin nor flucloxacillin increases the risk of stroke/systemic embolism in direct oral …
Aim We aimed to assess if dicloxacillin/flucloxacillin reduces the therapeutic efficacy of direct
oral anticoagulants (DOACs) and the underlying molecular mechanism. Methods In a …
oral anticoagulants (DOACs) and the underlying molecular mechanism. Methods In a …
Pharmacokinetics–Pharmacodynamics Modeling for Evaluating Drug–Drug Interactions in Polypharmacy: Development and Challenges
D Zhao, P Huang, L Yu, Y He - Clinical Pharmacokinetics, 2024 - Springer
Polypharmacy is commonly employed in clinical settings. The potential risks of drug–drug
interactions (DDIs) can compromise efficacy and pose serious health hazards. Integrating …
interactions (DDIs) can compromise efficacy and pose serious health hazards. Integrating …
Supporting safe use of antibiotics: Penicillinase-resistant penicillins as inducers of drug metabolism and drug transport
DB Iversen - 2023 - portal.findresearcher.sdu.dk
Drug-drug interactions (DDIs) can increase the risk of adverse events and therapeutic failure
and increase healthcare costs. Pharmacokinetic DDIs can be mediated through induction or …
and increase healthcare costs. Pharmacokinetic DDIs can be mediated through induction or …
Impact of drug-gene-disease interactions and diurnal variation on exogenous and endogenous renal transporter substrates: a physiologically based pharmacokinetic …
D Feick - 2022 - publikationen.sulb.uni-saarland.de
Adverse drug reactions depict one of the leading causes of death in developed countries
and can often be attributed to drug-drug, drug-gene and drug-disease interactions …
and can often be attributed to drug-drug, drug-gene and drug-disease interactions …