Genome-wide association studies (GWAS) have revealed important biological insights into
complex diseases, which are broadly expected to lead to the identification of new drug …

UK Biobank is a large-scale prospective study with deep phenoty** and genomic data. Its
open-access policy allows researchers worldwide, from academia or industry, to perform …

INTRODUCTION Proteins are essential functional units of the human body and represent
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …

Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven
by somatic driver mutations, affects over a third of people, yet remains poorly understood …

The endometrium, the mucosal lining of the uterus, undergoes dynamic changes throughout
the menstrual cycle in response to ovarian hormones. We have generated dense single-cell …

Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common
form of clonal mosaicism,,,–, yet our knowledge of the causes and consequences of this is …

Background Epidemiological and experimental evidence has linked chronic inflammation to
cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are …

Background Previous studies have linked gut microbiota with cancer etiology, but the
associations for specific gut microbiota are causal or owing to bias remain to be elucidated …

Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …

Background The risk of extracolonic cancer is increased in inflammatory bowel disease
(IBD) patients, but it is not clear whether there is a causal relationship. We aimed to …