Answer questions and earn CME/CNE Over the past 12 years, medical treatment for renal
cell carcinoma (RCC) has transitioned from a nonspecific immune approach (in the cytokine …

Angiogenesis has always been the topic of major scientific interest in the field of malignant
tumors. Nowadays, targeting angiogenesis has achieved success in various carcinomas by …

Evidence shows the quality of reporting of randomised controlled trials is not optimal. The
lack of transparent reporting impedes readers from judging the reliability and validity of trial …

The diagnosis and management of renal cell carcinoma have changed remarkably rapidly.
Although the incidence of renal cell carcinoma has been increasing, survival has improved …

There has been significant progress in the treatment of patients with advanced clear cell
renal cell carcinoma (ccRCC), with improved knowledge of disease biology and the …

Vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) have been the
mainstay of treatment for patients with advanced renal cell carcinoma (RCC). Despite its …

Introduction: Protein kinases are involved in various cellular functions. About 2% of the
human genome encodes for protein kinases. Dysregulation of protein kinases is implicated …

Context Systemic therapy for metastatic clear cell renal cell carcinoma (mccRCC) has
greatly evolved over the last 15 yr. More recently, combination strategies involving …

Summary Background In the phase 3 CheckMate 025 study, previously treated patients with
advanced renal cell carcinoma who were randomly assigned to nivolumab had an overall …

Kidney cancer represents about 5% of all new cancer diagnoses. The most common form of
kidney cancer arises from renal epithelium, named renal cell carcinoma (RCC). This entity …