Chemicals that are used experimentally to evoke itch elicit activity in diverse subpopulations
of cutaneous pruriceptive neurons, all of which also respond to painful stimuli. However, itch …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

The concept that G protein‐coupled receptors (GPCRs) can form hetero‐dimers or hetero‐
oligomers continues to gain experimental support. However, with the exception of the …

Pain remains a pervasive problem throughout medicine, transcending all specialty
boundaries. Despite the extraordinary insights into pain and its mechanisms over the past …

Abstract WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is
an immune deficiency linked in many cases to heterozygous mutations causing truncations …

The tetra-peptide FMRF-NH2 is a cardioexcitatory peptide in the clam. Using the antibody
against this peptide, FMRF-NH2-like immunoreactive material was detected in mammalian …

Functional defects in cilia are associated with various human diseases including congenital
hydrocephalus. Previous studies suggested that defects in cilia not only disrupt the flow of …

Mu opioid receptors modulate a large number of physiological functions. They are in
particular involved in the control of pain perception and reward properties. They are also the …

The endogenous neuropeptide FF (NPFF) and its two cognate G protein-coupled receptors,
Neuropeptide FF Receptors 1 and 2 (NPFFR1 and NPFFR2), represent a relatively new …

Opioid receptors are involved in the control of pain perception in the central nervous system
together with endogenous neuropeptides, termed opioid‐modulating peptides, participating …