Bromocriptine therapy: Review of mechanism of action, safety and tolerability

F Naz, A Malik, M Riaz, Q Mahmood… - Clinical and …, 2022 - Wiley Online Library
Bromocriptine is a sympatholytic dopamine D2 receptor agonist with remarkable
bioactivities. It has been used clinically as a prescription drug for more than 30 years to treat …

A metabolite perspective on the involvement of the gut microbiota in type 2 diabetes

Y Fu, S Li, Y **ao, G Liu, J Fang - International Journal of Molecular …, 2023 - mdpi.com
Type 2 diabetes (T2D) is a commonly diagnosed condition that has been extensively
studied. The composition and activity of gut microbes, as well as the metabolites they …

Peripheral dopamine directly acts on insulin-sensitive tissues to regulate insulin signaling and metabolic function

G Tavares, FO Martins, BF Melo, P Matafome… - Frontiers in …, 2021 - frontiersin.org
Dopamine is a key regulator of glucose metabolism in the central nervous system. However,
dopamine is also present in the periphery and may have direct effects on insulin-sensitive …

Receptors involved in mental disorders and the use of clozapine, chlorpromazine, olanzapine, and aripiprazole to treat mental disorders

R Mlambo, J Liu, Q Wang, S Tan, C Chen - Pharmaceuticals, 2023 - mdpi.com
Mental illnesses are a global health challenge, and effective medicines are needed to treat
these conditions. Psychotropic drugs are commonly prescribed to manage mental disorders …

Brain dopamine–clock interactions regulate cardiometabolic physiology: mechanisms of the observed cardioprotective effects of circadian-timed bromocriptine-QR …

AH Cincotta - International Journal of Molecular Sciences, 2023 - mdpi.com
Despite enormous global efforts within clinical research and medical practice to reduce
cardiovascular disease (s)(CVD), it still remains the leading cause of death worldwide. While …

Type 2 diabetes mellitus augments Parkinson's disease risk or the other way around: facts, challenges and future possibilities

M Faizan, A Sarkar, MP Singh - Ageing Research Reviews, 2022 - Elsevier
About 10% of the adult population is living with type 2 diabetes mellitus (T2DM) and 1% of
the population over 60 years of age is suffering from Parkinson's disease (PD). A school of …

Dopamine receptor D1 signaling stimulates lipolysis and browning of white adipocytes

J Yu, J Zhu, J Deng, J Shen, F Du, X Wu, Y Chen… - Biochemical and …, 2022 - Elsevier
Adipocytes express several kinds of catecholamine receptors, including adrenergic
receptors, and dopamine receptors. Signaling pathways mediated by catecholamine …

Dopamine receptor agonists mechanism of actions on glucose lowering and their connections with prolactin actions

HY Chien, SM Chen, WC Li - Frontiers in Clinical Diabetes and …, 2023 - frontiersin.org
Robust experiment evidence suggests that prolactin can enhance beta-cell proliferation and
increase insulin secretion and sensitivity. Apart from acting as an endocrine hormone, it also …

Vitamin D status determines cardiometabolic effects of cabergoline in women with elevated prolactin levels: A pilot study

R Krysiak, M Basiak, G Machnik, W Szkróbka… - Nutrients, 2023 - mdpi.com
Both hyperprolactinemia and vitamin D deficiency appear to be associated with increased
cardiometabolic risk. This study aimed to determine whether vitamin D status influences the …

Multi‐tissue transcriptome‐wide association study reveals susceptibility genes and drug targets for insulin resistance‐relevant phenotypes

YY Duan, X Ke, H Wu, S Yao, W Shi… - Diabetes, Obesity …, 2024 - Wiley Online Library
Aim Genome‐wide association studies (GWAS) have identified multiple susceptibility loci
associated with insulin resistance (IR)‐relevant phenotypes. However, the genes …