Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are heterogeneous
regarding site of origin, biological behavior, and malignant potential. There has been a rapid …

The autosomal dominantly inherited disorder von Hippel–Lindau disease (VHL) is caused
by germline mutations in the VHL tumour suppressor gene (TSG). VHL mutations …

Abstract von Hippel Lindau disease (vHL) is caused by a hereditary predisposition to
multiple neoplasms, especially hemangioblastomas in the retina and CNS, renal cell …

Dominantly inherited tumor-prone syndromes are a significant health burden, but disease-
related morbidity can be reduced and life expectancy increased by a GR type approach …

A gene discovered by positional cloning has been identified as the von Hippel-Lindau (VHL)
disease tumor suppressor gene. A restriction fragment encompassing the gene showed …

Summary von Hippel-Lindau disease is a heritable multisystem cancer syndrome that is
associated with a germline mutation of the VHL tumour suppressor gene on the short arm of …

Multiple, bilateral renal carcinomas are a frequent occurrence in von Hippel–Lindau (VHL)
disease. To elucidate the aetiological role of the VHL gene in human kidney tumorigenesis …

This book on the World Health Organization (WHO) classification of tumours of the nervous
system reflects the view of a working group that convened for an editorial and consensus …

Purpose Genetic factors have been implicated in the pathogenesis of renal cell carcinoma
(RCC), with around 3% of cases having a family history. A greater knowledge of the genetics …

Abstract The First International Symposium on Pheochromocytoma, held in October 2005,
included discussions about developments concerning these rare catecholamine-producing …