The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …

Nucleotide excision repair (NER) eliminates various structurally unrelated DNA lesions by a
multiwise'cut and patch'-type reaction. The global genome NER (GG-NER) subpathway …

Summary N 6-methyladenosine (m 6 A) modification occurs co-transcriptionally and impacts
pre-mRNA processing; however, the mechanism of co-transcriptional m 6 A-dependent …

Transcription-coupled DNA repair removes bulky DNA lesions from the genome, and
protects cells against ultraviolet (UV) irradiation. Transcription-coupled DNA repair begins …

Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which
threaten genome stability and cell viability. Cells have evolved two main repair pathways to …

Thalidomide-like drugs such as lenalidomide are clinically important treatments for multiple
myeloma and show promise for other B cell malignancies. The biochemical mechanisms …

Big Data bring new opportunities to modern society and challenges to data scientists. On the
one hand, Big Data hold great promises for discovering subtle population patterns and …

Transcription-coupled repair (TCR), discovered as preferential nucleotide excision repair of
UV-induced cyclobutane pyrimidine dimers located in transcribed mammalian genes …

Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B cell
neoplasms, but its mechanism of action is unknown. Using quantitative proteomics, we …

Nucleotide excision repair (NER) is the main pathway used by mammals to remove bulky
DNA lesions such as those formed by UV light, environmental mutagens, and some cancer …