Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase

RJ Obaid, N Naeem, EU Mughal, MM Al-Rooqi… - RSC …, 2022 - pubs.rsc.org
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …

Bioactive aurones, indanones, and other hemiindigoid scaffolds: Medicinal chemistry and photopharmacology perspectives

LM Lazinski, G Royal, M Robin… - Journal of Medicinal …, 2022 - ACS Publications
Hemiindigoids comprise a range of natural and synthetic scaffolds that share the same
aromatic hydrocarbon backbone as well as promising biological and optical properties. The …

Novel inhibitors with sulfamethazine backbone: synthesis and biological study of multi-target cholinesterases and α-glucosidase inhibitors

C Türkeş, S Akocak, M Işık, N Lolak… - Journal of …, 2022 - Taylor & Francis
The underlying cause of many metabolic diseases is abnormal changes in enzyme activity
in metabolism. Inhibition of metabolic enzymes such as cholinesterases (ChEs; …

Synthesis and evaluation of 1, 3, 5-triaryl-2-pyrazoline derivatives as potent dual inhibitors of urease and α-glucosidase together with their cytotoxic, molecular …

R Mehmood, A Sadiq, RI Alsantali, EU Mughal… - ACS …, 2022 - ACS Publications
In the present work, a concise library of 1, 3, 5-triaryl-2-pyrazolines (2a–2q) was designed
and synthesized by employing a multistep strategy, and the newly synthesized compounds …

DNA protection, molecular docking, antioxidant, antibacterial, enzyme inhibition, and enzyme kinetic studies for parietin, isolated from Xanthoria parietina (L.) Th. Fr.

S Yenigun, Y Ipek, S Marah, I Demirtas… - Journal of Biomolecular …, 2024 - Taylor & Francis
Parietin was isolated from Xanthoria parietina (L.) Th. Fr.'(methanol: chloroform) extract,
using a silica column. 13 C NMR and 1H NMR were used to confirm the structure of the …

Para-Substituted Thiosemicarbazones as Cholinesterase Inhibitors: Synthesis, In Vitro Biological Evaluation, and In Silico Study

M Khan, H Gohar, A Alam, A Wadood, A Shareef… - ACS …, 2023 - ACS Publications
The current research reports the synthesis of 14 para-substituted thiosemicarbazone
derivatives in good to excellent yields using standard procedures. Initially, 4 …

Synthesis and biological evaluation of substituted aurone derivatives as potential tyrosinase inhibitors: in vitro, kinetic, QSAR, docking and drug-likeness studies

NA Alshaye, EU Mughal, EB Elkaeed… - Journal of …, 2023 - Taylor & Francis
Tyrosinase enzyme plays an essential role in melanin biosynthesis and enzymatic browning
of fruits and vegetables. To discover potent tyrosinase inhibitors, the present studies were …

Synthetic flavonoids as potential antiviral agents against SARS-CoV-2 main protease

F Batool, EU Mughal, K Zia, A Sadiq… - Journal of …, 2022 - Taylor & Francis
The COVID-19 pandemic has claimed more than a million lives worldwide within a short
time span. Due to the unavailability of specific antiviral drugs or vaccine, the infections are …

Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis

D Lin, S Jiang, A Zhang, T Wu, Y Qian… - Natural products and …, 2022 - Springer
Structural derivatization of natural products has been a continuing and irreplaceable source
of novel drug leads. Natural phenols are a broad category of natural products with wide …

2-Benzylidenebenzofuran-3 (2 H)-ones as a new class of alkaline phosphatase inhibitors: synthesis, SAR analysis, enzyme inhibitory kinetics and computational …

J Ashraf, EU Mughal, RI Alsantali, A Sadiq, RS Jassas… - RSC …, 2021 - pubs.rsc.org
The excelling role of organic chemistry in the medicinal field continues to be one of the main
leads in the drug development process. Particularly, this industry requires organic chemists …