Cerebral amyloid angiopathy and Alzheimer disease—one peptide, two pathways

SM Greenberg, BJ Bacskai… - Nature Reviews …, 2020 - nature.com
The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …

Emerging concepts in sporadic cerebral amyloid angiopathy

A Charidimou, G Boulouis, ME Gurol, C Ayata… - Brain, 2017 - academic.oup.com
Sporadic cerebral amyloid angiopathy is a common, well-defined small vessel disease and
a largely untreatable cause of intracerebral haemorrhage and contributor to age-related …

HDL from an Alzheimer's disease perspective

EB Button, J Robert, TM Caffrey, J Fan… - Current opinion in …, 2019 - journals.lww.com
Evidence from human studies, animal models, and bioengineered arteries supports the
hypothesis that HDL protects against cerebrovascular dysfunction in Alzheimer's disease …

Transendothelial transport of lipoproteins

E Jang, J Robert, L Rohrer, A von Eckardstein, WL Lee - Atherosclerosis, 2020 - Elsevier
The accumulation of low-density lipoproteins (LDL) in the arterial wall plays a pivotal role in
the initiation and pathogenesis of atherosclerosis. Conversely, the removal of cholesterol …

Differences in the cerebral amyloid angiopathy proteome in Alzheimer's disease and mild cognitive impairment

D Leitner, T Kavanagh, E Kanshin, K Balcomb… - Acta …, 2024 - Springer
Cerebral amyloid angiopathy (CAA) is characterized by amyloid beta (Aβ) deposition in
cerebrovasculature. It is prevalent with aging and Alzheimer's disease (AD), associated with …

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

AM Wojtas, SS Kang, BM Olley… - Proceedings of the …, 2017 - National Acad Sciences
Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) peptide deposition in brain
parenchyma as plaques and in cerebral blood vessels as cerebral amyloid angiopathy …

Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer's disease

DC Hondius, KN Eigenhuis, THJ Morrema… - Acta Neuropathologica …, 2018 - Springer
Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) deposits as plaques in the
parenchyma and in the walls of cortical and leptomeningeal blood vessels of the brain …

CADASIL brain vessels show a HTRA1 loss-of-function profile

A Zellner, E Scharrer, T Arzberger, C Oka… - Acta …, 2018 - Springer
Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) and a phenotypically similar recessive condition …

Proteomics of neurodegenerative diseases: analysis of human post‐mortem brain

KW Li, AB Ganz, AB Smit - Journal of neurochemistry, 2019 - Wiley Online Library
Dementias are prevalent brain disorders in the aged population. Dementias pose major
socio‐medical burden, but currently there is no cure available. Novel proteomics …

[HTML][HTML] Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates

A Zellner, SA Müller, B Lindner, N Beaufort… - Acta neuropathologica …, 2022 - Springer
Cerebral amyloid angiopathy (CAA) is an age-related condition and a major cause of
intracerebral hemorrhage and cognitive decline that shows close links with Alzheimer's …