The key regulators of the transcriptional response to hypoxia and inflammation (hypoxia
inducible factor, HIF, and nuclear factor-kappa B, NF-κB, respectively) are evolutionarily …

Humans and their domestic animals have lived and thrived in high-altitude environments
worldwide for thousands of years. These populations have developed a number of …

Human genomics is witnessing an ongoing paradigm shift from a single reference sequence
to a pangenome form, but populations of Asian ancestry are underrepresented. Here we …

Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here,
we report that genes involved in various human cancers evolved rapidly in Tibetans and six …

Underrepresentation of non-European (EUR) populations hinders growth of global precision
medicine. Resources such as imputation reference panels that match the study population …

As the most prevalent aboriginal group on Hainan Island located between South China and
the mainland of Southeast Asia, the Li people are believed to preserve some unique genetic …

Ascent to high altitude is associated with physiological responses that counter the stress of
hypobaric hypoxia by increasing oxygen delivery and by altering tissue oxygen utilisation …

As the largest ethnic group in the world, the Han Chinese population is nonetheless
underrepresented in global efforts to catalogue the genomic variability of natural …

Abstract The Tibetan Plateau is populated by diverse ethnic groups, but most of them are
underrepresented in genomics studies compared with the Tibetans (TIB). Here, to gain …

Tibeto-Burman (TB) people have endeavored to adapt to the hypoxic, cold, and high-UV
high-altitude environments in the Tibetan Plateau and complex disease exposures in …