Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also
imposes a severe economic burden on patients and society. Among symptomatic LBP …

Since the identification and characterization of gasdermin (GSDM) D as the main effector of
inflammatory regulated cell death (or pyroptosis), literature on the GSDM family of pore …

The absence of tumor antigens leads to a low response rate, which represents a major
challenge in immune checkpoint blockade (ICB) therapy. Pyroptosis, which releases tumor …

Excess accumulation of mitochondrial reactive oxygen species (mtROS) is a key target for
inhibiting pyroptosis‐induced inflammation and tissue damage. However, targeted delivery …

Cathepsin B (CTSB), a member of lysosomal cathepsin, is involved in cell autophagy and
apoptosis. We previously reported that CTSB increased cardiomyocyte apoptosis in mice …

NLRP3 inflammasome mediated pyroptosis is involved in cadmium exposure-induced
neuroinflammation through the IL-1β/IkB-α-NF-κB-NLRP3 feedback loop in swine …

Aflatoxin B1 (AFB1), a potent food-borne hepatocarcinogen, is the most toxic aflatoxin that
induces liver injury in humans and animals. Species-specific sensitivities of aflatoxins …

The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A
(GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD) …

Although accumulating evidence indicates that exosomes have a positive therapeutic effect
on hepatic ischemia–reperfusion injury (HIRI), studies focusing on the alleviation of liver …

Intervertebral disc degeneration (IVDD) is a common musculoskeletal degenerative disease
worldwide, of which the main clinical manifestation is low back pain (LBP); approximately …