[HTML][HTML] The role of mitochondria in oocyte maturation
A Kirillova, JEJ Smitz, GT Sukhikh, I Mazunin - Cells, 2021 - mdpi.com
With the nucleus as an exception, mitochondria are the only animal cell organelles
containing their own genetic information, called mitochondrial DNA (mtDNA). During oocyte …
containing their own genetic information, called mitochondrial DNA (mtDNA). During oocyte …
Mitochondrial dynamics and inheritance during cell division, development and disease
P Mishra, DC Chan - Nature reviews Molecular cell biology, 2014 - nature.com
During cell division, it is critical to properly partition functional sets of organelles to each
daughter cell. The partitioning of mitochondria shares some common features with that of …
daughter cell. The partitioning of mitochondria shares some common features with that of …
[HTML][HTML] The role of mitochondria in aging
A Bratic, NG Larsson - The Journal of clinical investigation, 2013 - jci.org
Over the last decade, accumulating evidence has suggested a causative link between
mitochondrial dysfunction and major phenotypes associated with aging. Somatic …
mitochondrial dysfunction and major phenotypes associated with aging. Somatic …
Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA
Mammalian mtDNA is packaged in DNA-protein complexes denoted mitochondrial
nucleoids. The organization of the nucleoid is a very fundamental question in mitochondrial …
nucleoids. The organization of the nucleoid is a very fundamental question in mitochondrial …
Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos
Mitochondrial DNA (mtDNA) mutations cause inherited diseases and are implicated in the
pathogenesis of common late-onset disorders, but how they arise is not clear,. Here we …
pathogenesis of common late-onset disorders, but how they arise is not clear,. Here we …
A mitochondrial bioenergetic etiology of disease
DC Wallace - The Journal of clinical investigation, 2013 - jci.org
The classical Mendelian genetic perspective has failed to adequately explain the biology
and genetics of common metabolic and degenerative diseases. This is because these …
and genetics of common metabolic and degenerative diseases. This is because these …
Somatic mitochondrial DNA mutations in mammalian aging
NG Larsson - Annual review of biochemistry, 2010 - annualreviews.org
Mitochondrial dysfunction is heavily implicated in the multifactorial aging process. Aging
humans have increased levels of somatic mtDNA mutations that tend to undergo clonal …
humans have increased levels of somatic mtDNA mutations that tend to undergo clonal …
Mitochondrial DNA mutations in disease and aging
CB Park, NG Larsson - Journal of cell biology, 2011 - rupress.org
© 2011 Park and Larsson This article is distributed under the terms of an Attribution–
Noncommercial–Share Alike–No Mirror Sites license for the first six months after the …
Noncommercial–Share Alike–No Mirror Sites license for the first six months after the …
[HTML][HTML] mtDNA heteroplasmy: origin, detection, significance, and evolutionary consequences
ME Parakatselaki, ED Ladoukakis - Life, 2021 - mdpi.com
Mitochondrial DNA (mtDNA) is predominately uniparentally transmitted. This results in
organisms with a single type of mtDNA (homoplasmy), but two or more mtDNA haplotypes …
organisms with a single type of mtDNA (homoplasmy), but two or more mtDNA haplotypes …
The rate and nature of mitochondrial DNA mutations in human pedigrees
ER Árnadóttir, KHS Moore, VB Guðmundsdóttir… - Cell, 2024 - cell.com
We examined the rate and nature of mitochondrial DNA (mtDNA) mutations in humans using
sequence data from 64,806 contemporary Icelanders from 2,548 matrilines. Based on …
sequence data from 64,806 contemporary Icelanders from 2,548 matrilines. Based on …