Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Hydrogen/deuterium exchange (HDX) mass spectrometry (MS) has become a key technique
for monitoring structural and dynamic aspects of proteins in solution. This approach relies on …

The activation of G proteins by G protein-coupled receptors (GPCRs) underlies the majority
of transmembrane signaling by hormones and neurotransmitters. Recent structures of GPCR …

INTRODUCTION The ubiquitin-proteasome system comprises hundreds of distinct pathways
of degradation, which converge at the step of ubiquitin recognition by the proteasome. Five …

G protein-coupled receptors represent the largest family of membrane receptors that
instigate signalling through nucleotide exchange on heterotrimeric G proteins. Nucleotide …

The folding and misfolding mechanism of multidomain proteins remains poorly understood.
Although thermodynamic instability of the first nucleotide-binding domain (NBD1) of ΔF508 …

Myriad biological processes proceed through states that defy characterization by
conventional atomic-resolution structural biological methods. The invisibility of these …

Hydrogen/deuterium exchange (HDX) mass spectrometry (MS) emerged as a tool for
biochemistry and structural biology around 25 years ago. It has since become a key …

The C5a receptor (C5aR) is a G-protein-coupled receptor (GPCR) that can induce strong
inflammatory response to the anaphylatoxin C5a. Targeting C5aR has emerged as a novel …